Our aim was to determine the effects of 12 h of hypoxaemia on cerebral blood flow (CBF) and cerebral O2 delivery in ovine fetuses at 0.6 gestation. During fetal hypoxaemia, induced by reduced uterine blood flow, fetal SaO2 and PaO2 were reduced (p < 0.01) from control values of 77.0 +/- 1.6% and 27.3 +/- 1.0 mm Hg, respectively, to 28.4 +/- 3.4% and 15.6 +/- 0.6 mm Hg; fetal pHa decreased from control values of 7.37 +/- 0.01 to 7.20 +/- 0.02 at 3 h, but returned to control values before 12 h. CBF (ml/min/100 g) was 2.0- to 2.6-fold higher (p < 0.01) than control values during hypoxaemia, but only 1.7-fold higher (p < 0.01) at 3 h when pHa was lowest. Cerebral O2 delivery (ml/min/100 g) was lower (p < 0.01) than control values of 3.15 +/- 0.29 at 1.5h (2.09 +/- 0.36) and 3h (1.84 +/- 0.22) of hypoxaemia and higher 1 h after hypoxaemia had ceased (3.81 +/- 0.22, p < 0.01). We conclude that the ovine fetus at 0.6 gestation is unable to sustain increased CBF and hence maintain cerebral O2 delivery during the first 6 h of hypoxaemia, a time which coincides with acidaemia; in contrast, at 6 and 12 h of hypoxaemia, when pHa was normal, cerebral O2 delivery was similar to control values. Reduced cerebral O2 delivery during the early, acidaemic, stages of hypoxaemia may lead to impaired neural development.

译文

我们的目的是确定低氧血症12 h对0.6胎的绵羊胎儿脑血流量(CBF)和脑O2输送的影响。在因子宫血流量减少而引起的胎儿低氧血症期间,胎儿的SaO2和PaO2从对照值分别从控制值77.0 /-1.6%和27.3 /-1.0 mm Hg降低(p <0.01)分别降至28.4 /-3.4%和15.6 / -0.6毫米汞柱;胎儿pHa在3 h时从7.37 /-0.01的控制值降低到7.20 /-0.02,但在12 h之前恢复到控制值。低氧血症期间的CBF(ml / min / 100 g)比对照值高2.0到2.6倍(p <0.01),但在pHa最低的3 h时,CBF仅高1.7倍(p <0.01)。低氧血症1.5h(2.09 /-0.36)和低氧血症3h(1.84 /-0.22)时,脑氧输送量(ml / min / 100 g)低于(3.15 /-0.29)对照值(p <0.01),高于1 h后的对照值低氧血症已经停止(3.81 / 0.22,p <0.01)。我们得出的结论是,妊娠0.6的绵羊胎儿不能维持增加的CBF,因此在低氧血症的前6小时(与酸血症相吻合的时间)内不能维持脑氧的输送。相反,在低氧血症的6小时和12小时,当pHa正常时,脑中O2的输送与对照值相似。低氧血症早期,酸性血症阶段的大脑O2输送减少可能导致神经发育受损。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录