PURPOSE:To analyze the repeatability of thickness measurements of the central macula, ganglion cell-inner plexiform layer (GC-IPL), and retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography (SD-OCT) before and after treatment of macular edema in branch retinal vein occlusion (BRVO). METHODS:We analyzed patients with BRVO who visited our retinal clinic. The repeatability of the thickness measurements were compared using the intraclass correlation coefficient (ICC) and coefficient of variation (COV) of affected versus normal fellow eyes. RESULTS:The average thicknesses of the central macula, RNFL, and GC-IPL were 371.28 μm, 105.60 μm, and 61.88 μm, respectively, in affected eyes with macular edema before treatment, and the ICCs were 0.978, 0.919, and 0.705, respectively. The average thicknesses were 244.98 μm, 96.70 μm, and 82.70 μm, respectively, in affected eyes without macular edema after treatment, and the ICCs were 0.999, 0.975, and 0.928, respectively. After resolution of macular edema, the average thickness of the GC-IPL increased, whereas that of the central macula and RNFL significantly decreased (P < 0.05); all of the ICCs increased compared to pretreatment values. In normal fellow eyes, the average thicknesses were 250.98 μm, 93.50 μm, and 83.84 μm, respectively, and the ICCs were 0.996, 0.995, and 0.994, respectively. CONCLUSIONS:After treatment of macular edema, the repeatability and thickness of the GC-IPL increased, along with reduction in the central macular thickness. This resulted from auto-segmentation errors following macular contour changes and unstable gazes of the patients due to decreased visual acuities in BRVO with macular edema.

译文

目的:分析治疗前后使用光谱域光学相干断层扫描(SD-OCT)对中央黄斑,神经节细胞内丛状层(GC-IPL)和视网膜神经纤维层(RNFL)进行厚度测量的可重复性黄斑水肿在视网膜分支静脉阻塞(BRVO)中的作用。
方法:我们分析了就诊于视网膜诊所的BRVO患者。使用组内相关系数(ICC)和受影响的与正常的另一只眼睛的变异系数(COV)比较了厚度测量值的可重复性。
结果:治疗前患黄斑水肿的眼睛中央黄斑,RNFL和GC-IPL的平均厚度分别为371.28μm,105.60μm和61.88μm,ICC分别为0.978、0.919和0.705 。治疗后无黄斑水肿的患眼平均厚度分别为244.98μm,96.70μm和82.70μm,ICC分别为0.999、0.975和0.928。黄斑水肿消退后,GC-IPL的平均厚度增加,而中央黄斑和RNFL的平均厚度显着减少(P <0.05);与预处理值相比,所有ICC均增加。在正常同伴眼中,平均厚度分别为250.98μm,93.50μm和83.84μm,ICC分别为0.996、0.995和0.994。
结论:治疗黄斑水肿后,GC-IPL的可重复性和厚度增加,中央黄斑中心厚度减少。这是由于黄斑水肿导致BRVO视力下降导致黄斑轮廓改变后患者的自动分割错误和注视不稳定所导致的。

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