Myocardial extracellular volume fraction (ECV) reflecting diffuse myocardial fibrosis can be measured with T1 mapping cardiovascular magnetic resonance (CMR) before and after the application of a gadolinium-based extracellular contrast agent. The equilibrium between blood and myocardium contrast concentration required for ECV measurements can be obtained with a primed contrast infusion (equilibrium contrast-CMR). We hypothesized that equilibrium can also be achieved with a single contrast bolus to accurately measure diffuse myocardial fibrosis in patients with congenital heart disease (CHD). Healthy controls (n = 17; median age 24.0 years) and patients with CHD (n = 19; 25.0 years) were prospectively enrolled. Using modified Look-Locker inversion recovery T1 mapping before, 15 min after bolus injection, and during constant infusion of gadolinium-DOTA, T1 values were obtained for blood pool and myocardium of the left ventricle (LV), the interventricular septum (IVS), and the right ventricle (RV) in a single midventricular plane in short axis or in transverse orientation. ECV of LV, IVS and RV by bolus-only and bolus-infusion correlated significantly in CHD patients (r = 0.94, 0.95, and 0.74; p < 0.01, respectively) and healthy controls (r = 0.96, 0.89, and 0.64; p < 0.05, respectively). Bland-Altman plots revealed no significant bias between the techniques for any of the analyzed regions. ECV of LV and RV myocardium measured by bolus-only T1 mapping agrees well with bolus-infusion measurements in patients with CHD. The use of a bolus-only approach facilitates the integration of ECV measurements into existing CMR imaging protocols, allowing for assessment of diffuse myocardial fibrosis in CHD in clinical routine.

译文

:应用基于g的细胞外造影剂前后,可通过T1映射心血管磁共振(CMR)来测量反映弥漫性心肌纤维化的心肌细胞外体积分数(ECV)。 ECV测量所需的血液和心肌造影剂浓度之间的平衡可通过灌注造影剂(平衡造影剂CMR)获得。我们假设通过单次对比推注也可以达到平衡,以准确测量先天性心脏病(CHD)患者的弥漫性心肌纤维化。前瞻性纳入健康对照组(n = 17);中位年龄24.0岁; CHD患者(n = 19; 25.0岁)。使用改良的Look-Locker反转恢复T1映射,在推注大剂量,之后15分钟以及在持续输注--DOTA期间,获得了左心室(LV),心室间隔(IVS)的血池和心肌的T1值,右心室(RV)在短心轴或横向方向的单个心室中平面内。仅推注和推注输注的LV,IVS和RV的ECV在CHD患者(分别为r = 0.94、0.95和0.74; p <0.01)和健康对照者(r = 0.96、0.89和0.64; p中显着相关)分别<0.05)。布兰德-奥特曼(Bland-Altman)图显示,任何被分析区域的技术之间均无明显偏差。通过仅推注T1测绘测得的LV和RV心肌的ECV与CHD患者的推注量测量非常吻合。仅推注方法的使用有助于将ECV测量值集成到现有的CMR成像协议中,从而可以在临床常规中评估CHD中弥漫性心肌纤维化。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录