PURPOSE:Hematopoietic stem cell transplantation (HSCT) is a cure for sickle cell disease (SCD) but frequently results in permanent sterility. The complications associated with oocyte cryopreservation and risks of future pregnancy are increased in SCD patients. This case report discusses risk reduction strategies and includes a literature review of pregnancy after HSCT. CASE:A 23-year-old woman underwent ovarian stimulation for fertility preservation resulting in cancelation due to acute pain crisis. She underwent a successful oocyte retrieval after exchange transfusion to decrease her hemoglobin S to 30%. This is the second report of a pain crisis in a woman with SCD undergoing oocyte banking. CONCLUSION(S):Women with SCD undergoing fertility preservation may be at increased risk of complications from ovarian stimulation. Risks in pregnancy after HSCT should also be considered before proceeding with fertility preservation.

译文

目的:造血干细胞移植(HSCT)可以治愈镰状细胞病(SCD),但通常会导致永久性不育。 SCD患者与卵母细胞冷冻保存相关的并发症和未来怀孕的风险增加。该病例报告讨论了降低风险的策略,并包括了HSCT后妊娠的文献综述。
案例:一名23岁妇女接受卵巢刺激以保持生育能力,并由于急性疼痛危机而取消治疗。交换输血后,她的卵母细胞恢复成功,使血红蛋白S降至30%。这是第二例有关患有卵母细胞沉积的SCD妇女的疼痛危机的报告。
结论:患有SCD的妇女在保持生育能力的情况下,卵巢刺激引起并发症的风险可能增加。在保留生育能力之前,还应考虑HSCT后怀孕的风险。

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