Several studies have shown a decline in human semen quality and increased risks of male subfertility. This paper provides an overview of the mechanisms of pesticide-induced reproductive toxicity and the effects on male fertility since exposure to pesticides may be one of the causes of these disorders. Pesticides may directly damage spermatozoa, alter Sertoli cell or Leydig cell function, or disrupt the endocrine function in any stage of hormonal regulation (hormone synthesis, release, storage, transport, and clearance; receptor recognition and binding; thyroid function; and the central nervous system). These mechanisms are described with respect to the effects of pesticide exposure in vitro and in vivo. In epidemiologic studies, effects on sperm quality and time to pregnancy are reviewed. Clear effects on male fertility have been demonstrated for some pesticides [eg, dibromochloropropane, ethylene dibromide]. But results from more recent studies are inconsistent, and no uniform conclusion can be drawn about the effects of pesticides on male reproduction.

译文

:多项研究表明,人类精液质量下降,男性不育症的风险增加。本文概述了农药引起的生殖毒性机理及其对男性生育力的影响,因为接触农药可能是造成这些疾病的原因之一。农药可在荷尔蒙调节的任何阶段(激素合成,释放,储存,运输和清除;受体识别和结合;受体识别和结合;甲状腺功能;以及中枢神经)直接破坏精子,改变Sertoli细胞或Leydig细胞功能,或破坏内分泌功能。系统)。关于体外和体内农药暴露的影响,描述了这些机制。在流行病学研究中,综述了对精子质量和怀孕时间的影响。对于某些农药(例如,二溴氯丙烷,二溴乙烷),已证明对男性生育力有明显影响。但是最近的研究结果并不一致,也无法就农药对雄性生殖的影响得出统一的结论。

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