We have assesed the actions as free radical scavengers and inhibitors on peroxidation of hesperidin and neohesperidin dihydrochalcone, two flavonoids, flavanone and dihydrochalcone respectively, as some of the pharmacological properties of flavonoids group have been related with these activities. Hesperidin just at 10(-4) and 5 · 10(-4)M is able to show a low inhibitory activity in the superoxide anion radicals (O(2)(-)) genesis (8.66 ± 1.40 and 11.69 ± 2.36% respectively), and on the non-enzymatic lipid peroxidation at 10(-3)M dose (9.78 ± 0.35%), without affecting the hydroxyl radical (•OH) formation, generated by the ascorbic acid-Fe(3+)-EDTA system. In the other hand, neohesperidin dihydrochalcone is an authentic antioxidant drug as tested at all doses. It showed a great scavenger activity and/or inhibition of formation on O(2)(-) radicals (31.53 - 84.62%) and a significant scavenging effect on OH radicals (6.00 - 23.49%), as well as an important inhibitory action on non-enzymatic lipid peroxidation (15.43-95.33%).

译文

:我们评估了自由基清除剂和抑制剂对橙皮苷和新橙皮苷二氢查尔酮,两种黄酮,黄烷酮和二氢查尔酮的过氧化的作用,因为类黄酮类的某些药理特性与这些活性有关。橙皮苷仅在10(-4)和5·10(-4)M时对超氧阴离子自由基(O(2)(-))的产生具有较低的抑制活性(分别为8.66±1.40和11.69±2.36% ),并且在10(-3)M剂量(9.78±0.35%)的非酶促脂质过氧化作用下,不影响抗坏血酸-Fe(3)-EDTA系统生成的羟基自由基(•OH)的形成。另一方面,新橙皮苷二氢查耳酮是一种经过验证的真正抗氧化剂,在所有剂量下均已测试。它显示出强大的清除剂活性和/或对O(2)(-)自由基的形成的抑制作用(31.53-84.62%)和对OH自由基的显着清除作用(6.00-23.49%),以及对OH自由基的重要抑制作用非酶脂质过氧化(15.43-95.33%)。

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