OBJECTIVES:To analyse the character of morphological changes occurring in a well defined peripheral nerve in humans exposed to vibration from hand held tools.

METHODS:Biopsies of the dorsal interosseus nerve just proximal to the wrist were taken from 10 men exposed to vibration and from 12 male age matched necropsy controls. The nerve was resected for pain relief either as the sole procedure or in conjunction with carpal tunnel release. All specimens were sectioned and examined by light microscopy in standard sections, thin epon sections, and teasing preparations.

RESULTS:The combined results of the analyses showed pathological changes in all 10 patients dominated by breakdown of myelin and by interstitial and perineurial fibrosis. All but one of the 12 controls were normal.

CONCLUSION:These findings often show severe nerve injury previously not described at this level. They indicate that demyelination may be the primary lesion in neuropathy induced by vibration followed by fibrosis associated with incomplete regeneration or with organisation of oedema. Vibration can induce structural changes in peripheral nerves just proximal to the wrist and such changes may constitute a structural component in carpal tunnel syndrome among people exposed to vibration. This may help to explain the poor results achieved by carpal tunnel release in these patients.

译文

目标:分析暴露在手持工具振动下的人的清晰外围神经中发生的形态变化的特征。

方法:腕部附近的背骨间神经取自10名受到振动的男性和12名与年龄匹配的尸检对照男性。可以单独或与腕管释放术一起切除神经以减轻疼痛。所有标本均进行切片,并在标准切片,薄切片切片和戏弄制剂中进行光学显微镜检查。

结果:分析的合并结果显示,所有10例患者中的病理改变通过髓磷脂的分解以及间质和神经周纤维化。除了12个对照中的一个以外,其他所有对照都正常。

结论:这些发现通常显示出严重的神经损伤,此水平以前没有描述。他们表明,脱髓鞘可能是振动引起的神经病的主要病变,继之以与再生不完全或水肿组织相关的纤维化。振动会导致腕部附近的周围神经结构发生变化,这种变化可能构成受到振动的人的腕管综合症的结构成分。这可能有助于解释这些患者通过腕管释放获得的不良结果。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录