PURPOSE OF REVIEW:Endocrine disrupting chemicals (EDCs) have been known for their ability to interfere with aspects of hormone action resulting in adverse health consequences among animals and humans; however, the effects of EDCs on human fecundity have shown inconsistent findings. This review summarizes the most recent epidemiologic literature from humans on the potential effects of female exposure to nonpersistent EDCs, specifically bisphenol A (BPA), phthalates, parabens, and triclosan, on fecundity, measured by markers of reproductive hormones, markers of ovulation or ovarian reserve, IVF outcomes, and time-to-pregnancy. RECENT FINDINGS:Although the epidemiologic literature on this topic is growing, the evidence supporting an association between female urinary concentrations of BPA, phthalates, parabens and triclosan, and fecundity remains unclear. The heterogeneous results could be due to methodological differences in recruitment populations (fertile vs. subfertile), study designs (prospective vs. retrospective), assessment of exposure (including differences in the number and timing of urine samples and differences in the analytical methods used to assess the urinary concentrations), residual confounding due to diet or other lifestyle factors, and coexposures to other chemicals. SUMMARY:At present, there is limited evidence to conclude that female exposure to nonpersistent EDCs affect fecundity in humans. Further studies focusing on exposure to mixtures of EDCs are needed.

译文

审查目的:破坏内分泌的化学物质(EDC)能够干扰荷尔蒙作用,从而给动物和人类带来不良的健康后果,因此而闻名。但是,EDC对人类繁殖力的影响显示出不一致的发现。这篇综述总结了人类的最新流行病学文献,这些文献通过雌性激素,排卵或卵巢的标志物,测量了女性暴露于非持久性EDC(特别是双酚A(BPA),邻苯二甲酸盐,对羟基苯甲酸酯和三氯生)对生殖力的潜在影响。储备,IVF结果和怀孕时间。
最近的调查结果:尽管有关该主题的流行病学文献正在增长,但尚不清楚证据表明女性尿液中BPA,邻苯二甲酸盐,对羟基苯甲酸酯和三氯生的浓度与生育力之间存在关联。异质性结果可能是由于招募人群(可育与亚不育),研究设计(前瞻性与回顾性),暴露评估(包括尿液样本的数量和时间的差异以及用于分析的分析方法的差异)的方法学差异造成的。评估尿液浓度),由于饮食或其他生活方式因素造成的残留混杂物以及与其他化学物质的共同暴露。
摘要:目前,只有很少的证据可以得出结论,即女性接触非持久性EDC会影响人类的生育能力。需要进一步研究,重点放在暴露于EDC混合物中。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录