The association between dietary fat and fertility is not well studied. We evaluated intakes of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids (TFA), ω-3 fatty acids, and ω-6 fatty acids in relation to fecundability in Danish and North American preconception cohort studies. Women who were attempting to become pregnant completed a validated food frequency questionnaire at baseline. Pregnancy status was updated bimonthly for 12 months or until pregnancy. Fecundability ratios (FR) and 95% confidence intervals were estimated using multivariable proportional probabilities regression. Intakes of total fat and saturated, monounsaturated, polyunsaturated, and ω-6 fatty acids were not appreciably associated with fecundability. TFA intake was associated with reduced fecundability in North American women (for the fourth quartile vs. the first, FR = 0.86, 95% confidence interval (CI): 0.71, 1.04) but not Danish women (for the fourth quartile vs. the first, FR = 1.04, 95% CI: 0.86, 1.25), though intake among Danish women was low. In North America, ω-3 fatty acid intake was associated with higher fecundability, but there was no dose-response relationship (among persons who did not use fish oil supplements: for the fourth quartile vs. the first, FR = 1.40, 95% CI: 1.13, 1.73); no association was found in Danish women, among whom low intake was rare. In the present study, high TFA intake and low ω-3 fatty acid intake were associated with reduced fecundity.

译文

:饮食脂肪与生育能力之间的关联尚未得到很好的研究。在丹麦和北美先验队列研究中,我们评估了总脂肪,饱和脂肪酸,单不饱和脂肪酸,多不饱和脂肪酸,反式脂肪酸(TFA),ω-3脂肪酸和ω-6脂肪酸的摄入量与生育能力的关系。 。试图怀孕的妇女在基线时完成了经过验证的食物频率问卷调查。怀孕状态每两个月更新一次,持续12个月或直到怀孕。使用多变量比例概率回归估计可可行性比(FR)和95%置信区间。总脂肪和饱和,单不饱和,多不饱和和ω-6脂肪酸的摄入量与生育力没有显着相关。在北美女性中,TFA摄入与生育能力降低相关(第四个四分位数与第一个四分位数,FR = 0.86,95%置信区间(CI):0.71、1.04),但丹麦女性则没有(第四个四分位数与第一个四分位数)。 ,FR = 1.04,95%CI:0.86,1.25),尽管丹麦女性的摄入量较低。在北美,ω-3脂肪酸的摄入与较高的生育力相关,但没有剂量反应关系(在未使用鱼油补充剂的人群中:第四个四分位数与第一个四分位数的人相比,FR = 1.40,95% CI:1.13、1.73);在丹麦妇女中没有发现关联,其中低摄入量很少见。在本研究中,高TFA摄入量和低ω-3脂肪酸摄入量与生育力降低相关。

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