OBJECTIVE:To evaluate the association between adiposity, physical activity (PA), and fecundability. DESIGN:Prospective cohort study. SETTING:Not applicable. PATIENT(S):A total of 2,062 female pregnancy planners from the United States and Canada who were enrolled during the preconception period. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Self-reported pregnancy. Fecundability ratios (FRs) and 95% confidence intervals (CIs) were estimated using proportional probabilities models that adjusted for potential confounders. RESULT(S):Relative to body mass index (BMI) 18.5-24 kg/m(2), FRs for BMI <18.5, 25-29, 30-34, 35-39, 40-44, and ≥45 kg/m(2) were 1.05 (95% CI 0.76-1.46), 1.01 (95% CI 0.89-1.15), 0.98 (95% CI 0.82-1.18), 0.78 (95% CI 0.60-1.02), 0.61 (95% CI 0.42-0.88), and 0.42 (95% CI 0.23-0.76), respectively. Reduced fecundability was observed among women with the largest waist-to-hip ratios (≥0.85 vs. <0.75; FR = 0.87, 95% CI 0.74-1.01) and waist circumferences (≥36 vs. <26 inches [≥90 vs. <66 cm]; FR = 0.80, 95% CI 0.59-1.01). Tendency to gain weight in the chest/shoulders (FR = 0.63, 95% CI 0.36-1.08) and waist/stomach (FR = 0.90, 95% CI 0.79-1.02), relative to hips/thighs, was associated with lower fecundability. Moderate PA was associated with increased fecundability (≥5 vs. <1 h/wk; FR = 1.26, 95% CI 0.96-1.65), but there was no dose-response relation. Among overweight/obese women (BMI ≥25 kg/m(2)), fecundability was 27% higher for vigorous PA of ≥5 versus <1 h/wk (95% CI 1.02-1.57). CONCLUSION(S):Various measures of overall and central adiposity were associated with decreased fertility among pregnancy planners. Vigorous PA was associated with improved fertility among overweight and obese women only; moderate PA was associated with improved fertility among all women.

译文

目的:评估肥胖,体力活动(PA)和生育能力之间的关联。
设计:前瞻性队列研究。
设置:不适用。
患者:在孕前期共招募了2,062位来自美国和加拿大的女性怀孕计划人员。
干预措施:无。
主要观察指标:自我报告的妊娠。使用针对潜在混杂因素进行调整的比例概率模型估算可可行性比(FRs)和95%置信区间(CIs)。
结果(S):相对于体重指数(BMI)18.5-24 kg / m(2),BMI的FRs <18.5、25-29、30-34、35-39、40-44和≥45kg / m(2)分别为1.05(95%CI 0.76-1.46),1.01(95%CI 0.89-1.15),0.98(95%CI 0.82-1.18),0.78(95%CI 0.60-1.02),0.61(95%CI 0.61-1.02),0.61(95%CI 0.60-1.02),0.61(95%CI 0.42-0.88)和0.42(95%CI 0.23-0.76)。在腰臀比最大的女性(≥0.85vs. <0.75; FR = 0.87,95%CI 0.74-1.01)和腰围(≥36vs. <26英寸[≥90vs.]的女性中,生育力降低。 <66厘米]; FR = 0.80,95%CI 0.59-1.01)。相对于臀部/大腿,胸部/肩膀(FR = 0.63,95%CI 0.36-1.08)和腰部/胃(FR = 0.90,95%CI 0.79-1.02)增重的趋势与较低的生育能力相关。中度PA与生育力增加相关(≥5vs. <1 h / wk; FR = 1.26,95%CI 0.96-1.65),但没有剂量反应关系。在超重/肥胖女性(BMI≥25 kg / m(2))中,≥5的剧烈PA的生育能力比<1 h / wk高(27%CI 1.02-1.57)。
结论:各种总体和中央肥胖测量指标与计划生育者生育力下降有关。剧烈的PA仅与超重和肥胖妇女的生育能力有关;中度PA与所有妇女的生育能力提高有关。

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