OBJECTIVE:To investigate the extent to which fecundability is associated with active smoking, time since smoking cessation, and passive smoking. DESIGN:Prospective cohort study. SETTING:Denmark, 2007-2011. PATIENT(S):A total of 3,773 female pregnancy planners aged 18-40 years. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Self-reported pregnancy. Fecundability ratios (FRs) and 95% confidence intervals (CIs) were estimated using a proportional probabilities model that adjusted for menstrual cycle at risk and potential confounders. RESULT(S):Among current smokers, smoking duration of ≥10 years was associated with reduced fecundability compared with never smokers (FR, 0.85, 95% CI 0.72-1.00). Former smokers who had smoked ≥10 pack-years had reduced fecundability regardless of when they quit smoking (1-1.9 years FR, 0.83, 95% CI 0.54-1.27; ≥2 years FR, 0.73, 95% CI 0.53-1.02). Among never smokers, the FRs were 1.04 (95% CI 0.89-1.21) for passive smoking in early life and 0.92 (95% CI 0.82-1.03) for passive smoking in adulthood. CONCLUSION(S):Among Danish pregnancy planners, cumulative exposure to active cigarette smoking was associated with delayed conception among current and former smokers. Time since smoking cessation and passive smoking were not appreciably associated with fecundability.

译文

目的:探讨生育能力与主动吸烟,戒烟时间和被动吸烟相关的程度。
设计:前瞻性队列研究。
地点:丹麦,2007-2011年。
患者:共有3,773位18-40岁的女性怀孕计划者。
干预措施:无。
主要观察指标:自我报告的妊娠。使用比例概率模型估算可受孕率(FRs)和95%置信区间(CIs),该模型针对处于危险和潜在混杂因素的月经周期进行了调整。
结果:在目前的吸烟者中,与不吸烟者相比,吸烟时间≥10年与生育能力降低相关(FR,0.85,95%CI 0.72-1.00)。抽烟≥10包年的前吸烟者,无论何时戒烟,生育力都会降低(1-1.9岁FR,0.83,95%CI 0.54-1.27;≥2岁FR,0.73,95%CI 0.53-1.02)。在从不吸烟的人群中,早年被动吸烟的FRs为1.04(95%CI 0.89-1.21),成年后被动吸烟的FRs为0.92(95%CI 0.82-1.03)。
结论:在丹麦的怀孕计划者中,活跃吸烟者的累积暴露与现吸烟者和前吸烟者的受孕延迟有关。自戒烟和被动吸烟以来的时间与生育能力无关。

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