HIV-related fatigue is a debilitating and disabling symptom that persists for months and years. In 743 HIV/AIDS patients from Southern Africa, the authors found ratings of HIV-related fatigue to be highly prevalent. The authors conducted a secondary data analysis within the theoretical context of the University of California, San Francisco Symptom Management Model. The analysis focused on 538 patients who reported fatigue to investigate correlates and predictors of fatigue severity in relationship to demographic and HIV/AIDS illness indicators, as well as HIV-specific physical and psychological symptoms. A hierarchical regression model explored the contributions of those five blocks on fatigue severity. Of the 47% of the total variance in fatigue severity, a combination of variables within the health and illness block (6%), the physical symptoms block (7%) and the psychological symptom block (2%) contributed significantly to the increase in fatigue severity scores. Fatigue severity in Southern Africa was moderate, and the factors contributing to the perceived fatigue were most likely related to symptoms of acute HIV disease (such as fever and gastrointestinal problems). In conclusion, fatigue severity is less impacted by demographic or environmental variables but much more by co-occurring symptoms and HIV disease severity. The results of this study imply the need for more research to understand if improvements in water quality and access to food would prevent infection and diarrhea and whether sufficient access to antiretroviral treatments to manage the HIV infection would improve fatigue and co-occurring symptom profiles.

译文

与HIV相关的疲劳是一种令人衰弱和致残的症状,持续数月和数年。在来自南部非洲的743名HIV / AIDS患者中,作者发现与HIV相关的疲劳程度非常普遍。作者在加州大学旧金山分校症状管理模型的理论背景下进行了二次数据分析。该分析集中于538名报告疲劳的患者,以研究疲劳严重程度与人口统计学和HIV / AIDS疾病指标以及HIV特定的身体和心理症状的相关性和预测因素。分层回归模型探索了这五个区块对疲劳严重程度的贡献。在疲劳严重程度总变化的47%中,健康和疾病障碍(6%),身体症状障碍(7%)和心理症状障碍(2%)内的变量组合显着地增加了疲劳严重程度评分。南部非洲的疲劳严重程度是中等的,导致感觉疲劳的因素最有可能与急性HIV疾病的症状(如发烧和胃肠道问题)有关。总之,疲劳严重程度受人口或环境变量的影响较小,而受同时出现的症状和HIV疾病严重程度影响更大。这项研究的结果意味着需要进行更多的研究,以了解改善水质和获得食物是否可以预防感染和腹泻,以及获得抗逆转录病毒治疗药物来控制HIV感染是否会改善疲劳和并发症状。

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