This paper describes the prevalence of mood disturbance, sleep disturbance, fatigue and pain (MSFP), either alone or in combination in patients receiving cancer therapy, and determines its impact and whether it is a predictor for functional status and the impairment of quality of life (QoL). This is a cross-sectional study using secondary data from a sample of 214 patients being treated by chemotherapy or radiotherapy. In all, 87%, 68%, 66% and 38% of the patients reported MSFP respectively. Co-occurrence of any three and all of the four symptoms, were reported separately at rates of 29% and 31%. Patients with all four symptoms recorded significantly lower Karnofsky Performance Scale (KPS) scores (mean 77.7 ± 12.9) and QoL scores (mean subscales scores 9.0-17.6) than those with none or up to any three of the symptoms (P < 0.001). Regression of the KPS and QoL scores against the MSFP revealed an increase in the explained variance of 25%, 43%, 27%, 37% and 41% respectively for KPS, physical, emotional, functional and total QoL. The results suggest that MSFP are highly prevalent, whether alone or in combination, in patients receiving cancer therapy, and may negatively influence the patient's functional status and QoL during cancer therapy.

译文

:本文描述了接受癌症治疗的患者中单独或联合使用时情绪障碍,睡眠障碍,疲劳和疼痛(MSFP)的患病率,并确定其影响以及它是否是功能状态和质量下降的预测指标生活(QoL)。这是一项横断面研究,使用了来自214名正在接受化学疗法或放射疗法治疗的患者的样本的辅助数据。总计分别有87%,68%,66%和38%的患者报告了MSFP。分别报告了这三种症状和所有四种症状的并发发生率,分别为29%和31%。与没有或没有任何三种症状的患者相比,所有四种症状的患者记录的Karnofsky绩效量表(KPS)评分(平均77.7±12.9)和QoL评分(平均子评分为9.0-17.6)均显着降低(P <0.001)。 KPS和QoL得分相对于MSFP的回归显示,KPS,身体,情绪,功能和总QoL的解释方差分别增加了25%,43%,27%,37%和41%。结果表明,MSFP在接受癌症治疗的患者中非常普遍,无论是单独使用还是组合使用,都可能对癌症治疗期间的患者功能状态和QoL产生负面影响。

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