OBJECTIVE:To assess whether mothers and fathers have a higher long term risk of death, particularly from cardiovascular disease and cancer, after the mother has had pre-eclampsia. DESIGN:Population based cohort study of registry data. SUBJECTS:Mothers and fathers of all 626 272 births that were the mothers' first deliveries, recorded in the Norwegian medical birth registry from 1967 to 1992. Parents were divided into two cohorts based on whether the mother had pre-eclampsia during the pregnancy. Subjects were also stratified by whether the birth was term or preterm, given that pre-eclampsia might be more severe in preterm pregnancies. MAIN OUTCOME MEASURES:Total mortality and mortality from cardiovascular causes, cancer, and stroke from 1967 to 1992, from data from the Norwegian registry of causes of death. RESULTS:Women who had pre-eclampsia had a 1.2-fold higher long term risk of death (95% confidence interval 1.02 to 1.37) than women who did not have pre-eclampsia. The risk in women with pre-eclampsia and a preterm delivery was 2.71-fold higher (1.99 to 3.68) than in women who did not have pre-eclampsia and whose pregnancies went to term. In particular, the risk of death from cardiovascular causes among women with pre-eclampsia and a preterm delivery was 8.12-fold higher (4.31 to 15.33). However, these women had a 0.36-fold (not significant) decreased risk of cancer. The long term risk of death was no higher among the fathers of the pre-eclamptic pregnancies than the fathers of pregnancies in which pre-eclampsia did not occur. CONCLUSIONS:Genetic factors that increase the risk of cardiovascular disease may also be linked to pre-eclampsia. A possible genetic contribution from fathers to the risk of pre-eclampsia was not reflected in increased risks of death from cardiovascular causes or cancer among fathers.

译文

目的:评估母亲先兆子痫后,父亲和母亲是否有较高的长期死亡风险,尤其是死于心血管疾病和癌症。
设计:基于人群的注册表数据队列研究。
受试者:1967年至1992年在挪威医疗出生登记表中记录的626 272例母亲的首次分娩中,父母均为父亲。根据母亲在怀孕期间是否患有先兆子痫,将父母分为两个队列。考虑到先兆子痫在早产中可能更为严重,因此还根据出生是足月还是早产对受试者进行了分层。
主要观察指标:总死亡率和1967年至1992年期间因心血管原因,癌症和中风引起的死亡率,来自挪威死亡原因登记表的数据。
结果:患有先兆子痫的女性的长期死亡风险(95%置信区间1.02至1.37)比没有先兆子痫的女性高1.2倍。与先兆子痫和足月妊娠的妇女相比,先兆子痫和早产妇女的风险高2.71倍(1.99至3.68)。尤其是,先兆子痫和早产妇女因心血管原因死亡的风险要高8.12倍(4.31至15.33)。但是,这些女性患癌症的风险降低了0.36倍(不显着)。在先兆子痫孕妇中,长期死亡的风险并不比先兆子痫未发生者高。
结论:增加心血管疾病风险的遗传因素也可能与先兆子痫有关。父亲对先兆子痫风险的可能遗传贡献未反映在父亲因心血管原因或癌症死亡的风险增加中。

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