The aging process directly impacts bodily functions on multiple levels, including a reduced ability to resist stress, damage and disease. Besides changes in metabolic control, the aging process coincides with the altered long non-coding RNAs (lncRNAs) expression, which are ≥200nt long class of non-protein coding RNAs. The majority of non-coding transcripts of mammalian organs and tissues are expressed in developmentally regulated and cell-type specific manners. Specific altered lncRNA level has been involved in induction and maintenance of the whole human body aging with highly specific spatial andtemporal expression patterns. Furthermore, many lncRNAs are transcribed in sense, antisense and bidirectional manners in the mammalian genome. They play a vital role in regulating organ or tissue differentiation during aging by binding with miRNA or proteins to act as a decoy. Recently, the correlation between lncRNAs and aging has been studied intensely. Here, we have summarized some examples of known and novel lncRNAs that have been implicated in the aging process in the whole mammalian body and we discuss these patterns, conservation and characters during aging. This may further promote the development of research on lncRNAs and the aging process.

译文

衰老过程在多个层面上直接影响身体功能,包括抵抗压力、损伤和疾病的能力降低。除了代谢控制的变化外,衰老过程还与长非编码rna (lncRNAs) 表达的改变相吻合,长非编码rna是 ≥ 200nt长的非蛋白质编码rna。哺乳动物器官和组织的大多数非编码转录本以发育调节和细胞类型特定的方式表达。特定改变的lncRNA水平已参与诱导和维持具有高度特异性的时空表达模式的整个人体衰老。此外,许多lncrna在哺乳动物基因组中以有义,反义和双向方式转录。它们通过与miRNA或蛋白质结合作为诱饵,在衰老过程中调节器官或组织的分化中起着至关重要的作用。最近,人们对lncRNAs与衰老之间的相关性进行了深入研究。在这里,我们总结了一些已知和新型lncrna的例子,这些例子与整个哺乳动物体内的衰老过程有关,我们讨论了衰老过程中的这些模式,保存和特征。这可能会进一步促进lncRNAs和衰老过程研究的发展。

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