BACKGROUND:Post-thoracotomy adhesions are frequent postoperative complications. It has been reported that insoluble hyaluronic acid may prevent adhesions. MATERIALS AND METHODS:This study had two objectives: first, to determine the in vivo degradation and absorption process, as well as the intrathoracic retention, of solid insoluble hyaluronic acid membrane; and second, to elucidate the association between postoperative intrathoracic retention and the morphological changes of insoluble hyaluronic acid in 12 Wistar rats. Insoluble hyaluronic acid membranes were cut into 2.0 cm × 1.0 cm rectangles in a dry state. After weighing, the test membranes were soaked and washed with saline to be implanted after pericardiotomy via thoracotomy. At Days 4, 7, 10, 14, and 28 after implantation, the rats were euthanized, the chest was opened, and the condition and implantation site of the inserted test membrane were examined. RESULTS:Although approximately 10 days were required for the test membrane to decrease to half in the thoracic cavity, the intrathoracic remnant decreased to a mean of ~2% just 4 days later. CONCLUSION:This study clarified the time-dependent degradation process and remnants of insoluble hyaluronic acid in the thoracic cavity. A close relationship between the intrathoracic remnant of insoluble hyaluronic acid and its morphological change associated with degradation was demonstrated.

译文

背景:开胸术后粘连是术后常见的并发症。据报道,不溶性透明质酸可防止粘连。
材料与方法:这项研究有两个目标:第一,确定固体不溶性透明质酸膜的体内降解和吸收过程以及胸腔内保留。其次,阐明了12只Wistar大鼠术后胸腔内retention留与不溶性透明质酸形态变化之间的关系。在干燥状态下将不溶性透明质酸膜切成2.0×cm××1.0×cm的矩形。称重后,将测试膜浸泡并用盐水洗涤,以在经心包切开术后通过胸廓切开术植入。植入后第4、7、10、14和28天,对大鼠实施安乐死,打开胸腔,并检查插入的测试膜的状况和植入部位。
结果:尽管测试膜在胸腔中减少到一半需要大约10天的时间,但仅4天后,胸腔内残余物平均减少到〜2%。
结论:本研究阐明了胸腔中不溶性透明质酸的时间依赖性降解过程和残留。胸腔内残留的不透明质酸和其与降解相关的形态变化之间存在密切的关系。

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