BACKGROUND:Cardiovascular patients are likely to have an impaired health-related quality of life (HRQoL) due to functional and psycho-social limitations. The main objective of this study was to assess the distribution of HRQoL scores in coronary heart disease (CHD) patients across 22 European countries and to identify factors associated with the variation between patients. METHODS:Data from the EUROASPIRE III survey (European Action on Secondary and Primary Prevention by Intervention to Reduce Events), on 8734 patients, were used. Patients with a diagnosis of CHD (coronary artery bypass graft (CABG), percutaneous coronary intervention (PCI), acute myocardial infarction (AMI) or myocardial ischemia) were interviewed and examined at least 6 months after their acute coronary event. Quality of life of each patient was measured using 2 standardized questionnaires: the EuroQoL-5D (EQ-5D) and the 12-item short-form health survey (SF-12v2). RESULTS:HRQoL values differed significantly across countries. Lower HRQoL estimates were found in women, older patients, less educated patients, patients with myocardial infarction or ischemia as recruiting diagnosis, patients with a history of stroke and patients who suffered from a recurring CHD event. In addition, HRQoL was significantly associated with current smoking, central obesity, lack of exercise and inappropriate HbA1c control in patients with diabetes. Furthermore the number of risk factors is inversely associated with HRQoL. CONCLUSION:Overall, a large heterogeneity was observed in HRQoL values between countries and patient groups. There seems to be a significant association between quality of life and patient characteristics with lifestyle risk factors as important determinants of HRQoL.

译文

背景:由于功能和心理社会方面的限制,心血管疾病患者的健康相关生活质量(HRQoL)可能受损。这项研究的主要目的是评估HRQoL分数在22个欧洲国家中的冠心病(CHD)患者中的分布,并确定与患者之间差异相关的因素。
方法:使用EUROASPIRE III调查(欧洲通过干预减少事件的二级和一级预防行动)对8734例患者的数据。诊断为冠心病(冠状动脉搭桥术(CABG),经皮冠状动脉介入治疗(PCI),急性心肌梗塞(AMI)或心肌缺血)的患者在其急性冠状动脉事件发生后至少6个月进行了访谈和检查。每个患者的生活质量使用2份标准问卷进行测量:EuroQoL-5D(EQ-5D)和12个项目的简短健康调查(SF-12v2)。
结果:HRQoL值在不同国家之间存在显着差异。在女性,年龄较大的患者,受教育程度较低的患者,患有心肌梗塞或局部缺血的患者(作为招募诊断),有中风病史的患者以及患有复发性冠心病事件的患者中发现较低的HRQoL估计值。此外,HRQoL与糖尿病患者当前的吸烟,中心性肥胖,缺乏运动和不适当的HbA1c控制密切相关。此外,危险因素的数量与HRQoL成反比。
结论:总体而言,国家和患者群体之间的HRQoL值存在很大的异质性。生活质量和患者特征与作为HRQoL的重要决定因素的生活方式危险因素之间似乎存在显着联系。

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