The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.

译文

产气荚膜梭菌α毒素以前被认为是鸡坏死性肠炎的主要毒力因子,尽管尚未有确切的证据报道。在这项研究中,在有毒的鸡隔离株中构建了α-毒素突变体,并显示在鸡疾病模型中保留了全部毒力。这些结果表明,α-毒素不是鸡坏死性肠炎发病机理中必不可少的毒力因子。

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