We have previously shown in normal subjects that motor adaptation to imposed visual rotation is significantly enhanced when tested few days later. This occurs through a process of sleep-dependent memory consolidation. Here we ascertained whether patients with Parkinson's disease (PD) learn, improve, and retain new motor skills in the same way as normal subjects. We tested 16 patients in early stages of PD and 21 control subjects over two days. All subjects performed reaching movements on a digitizing tablet. Vision of the limb was precluded with an opaque screen; hand paths were shown on the screen with the targets' position. Unbeknownst to the subjects, the hand path on the screen was rotated by 30 degrees . In experiment 1, patients taking dopaminergic treatment and controls adapted to rotation with targets appearing in an unpredictable order. In experiment 2, drug-naïve patients and controls adapted to rotation in a less challenging task where target's appearance was predictable. Patients and controls made similar movements and adapted to rotation in the same way. However, when tested again over the following days, controls' performance significantly improved compared to training, while patients' performance did not. This lack of consolidation, which is present in the early stages of the disease and is independent from therapy, may be due to abnormal homeostatic processes that occur during sleep.

译文

:我们之前在正常受试者中显示,几天后进行测试后,运动适应视觉旋转的能力会大大增强。这是通过依赖于睡眠的内存合并过程来发生的。在这里,我们确定帕金森氏病(PD)的患者是否以与正常受试者相同的方式学习,改善和保留新的运动技能。我们在两天内测试了PD早期的16例患者和21例对照对象。所有对象均在数字化平板电脑上进行了移动动作。不透明的屏幕无法显示四肢的视力;屏幕上显示了目标位置的手形路径。被摄对象不知道,屏幕上的手部路径旋转了30度。在实验1中,接受多巴胺能治疗和控制的患者适应了旋转,并且靶标以无法预测的顺序出现。在实验2中,没有药物治疗的患者和对照组在难以预测的任务中适应了旋转,其中目标的出现是可预测的。患者和对照者进行相似的运动,并以相同的方式适应旋转。但是,在接下来的几天中再次进行测试时,与训练相比,对照组的表现显着改善,而患者的表现却没有。这种缺乏固结的现象是在疾病的早期阶段出现的,并且与治疗无关,这可能是由于睡眠期间发生的异常体内平衡过程引起的。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录