Alginate (ALA), which is an intercellular polysaccharide associated with brown algae, is used as a food additive, a health food and a medicine. Here, we first examined the adsorption of strontium (Sr) and cesium (Cs) by ALA in vitro, and then evaluated the effects of ALA on absorption and excretion of Sr and Cs in rats, in order to evaluate its potential usefulness for minimizing radiation damage from materials released after a nuclear accident. Both Sr and Cs were concentration-dependently adsorbed by sodium alginate (ALA-Na) in vitro. In rats given diet containing either ALA-Na or calcium alginate (ALA-Ca) for two weeks, the plasma concentration of Sr gradually decreased compared with the controls (normal diet); however, in the case of Cs, the plasma concentration was decreased only in the ALA-Ca group, but not the ALA-Na group. Moreover, we examined the effect of preadministration of diet containing either ALA-Na or ALA-Ca on absorption of Sr and Cs administered orally as the chloride salts to rats. Absorption of both Sr and Cs was reduced in the ALA-Ca group, while absorption of only Sr was reduced in the ALA-Na group. Safety assessments indicated that ALA-Ca is safer than ALA-Na. These results indicate that ALA-Ca reduces absorption and promotes excretion of both Sr and Cs, while ALA-Na does so only for Sr.

译文

:藻酸盐(ALA)是与褐藻相关的细胞间多糖,被用作食品添加剂,保健食品和药物。在这里,我们首先研究了ALA在体外对锶(Sr)和铯(Cs)的吸附,然后评估了ALA对大鼠中Sr和Cs吸收和排泄的影响,以评估其对最小化辐射的潜在有用性。核事故后释放的材料造成的损坏。海藻酸钠(ALA-Na)在体外对Sr和Cs均具有浓度依赖性的吸附作用。在饮食中含有ALA-Na或海藻酸钙(ALA-Ca)的大鼠中持续2周,与对照组相比,Sr的血浆浓度逐渐降低(正常饮食);在正常饮食中,Sr的血浆浓度逐渐降低。但是,在Cs的情况下,血浆浓度仅在ALA-Ca组中降低,而在ALA-Na组中未降低。此外,我们检查了预先饲喂含有ALA-Na或ALA-Ca的饮食对口服给予大鼠氯化物的Sr和Cs的吸收的影响。在ALA-Ca组中,Sr和Cs的吸收均降低,而在ALA-Na组中,仅Sr的吸收降低。安全评估表明,ALA-Ca比ALA-Na安全。这些结果表明,ALA-Ca减少了Sr和Cs的吸收并促进了排泄,而ALA-Na仅针对Sr了。

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