Recently completed molecular studies of poliovirus isolates suggest that viral replication of vaccine-related polioviruses may have persisted for as long as 7 years in a patient with vaccine-associated paralytic poliomyelitis (VAPP) in whom common variable immunodeficiency syndrome (CVID) previously had been diagnosed. This report summarizes the clinical and virologic data and discusses the possible implications of these new findings for the global polio eradication initiative, which include how and when to discontinue vaccination when polio has been eradicated.

译文

最近完成的脊髓灰质炎病毒分离株的分子研究表明,疫苗相关性脊髓灰质炎病毒的病毒复制在先前已被诊断出常见可变免疫缺陷综合症(CVID)的疫苗相关性麻痹性脊髓灰质炎(VAPP)患者中可能持续长达7年之久。 。本报告总结了临床和病毒学数据,并讨论了这些新发现对全球根除脊髓灰质炎行动的可能影响,包括根除脊髓灰质炎后如何以及何时停止接种疫苗。

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