Background:Patients with tuberculosis-destroyed lungs (TDLs), with airflow limitation, have clinical characteristics similar to those of patients with chronic obstructive pulmonary disease (COPD). Acute exacerbation is an important factor in the management of TDL. Therefore, the aim of this study was to investigate the factors associated with acute exacerbations in patients with stable TDL with airflow limitation.
Methods:We evaluated the clinical characteristics, such as lung function, image findings, and serum laboratory findings, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and interleukin (IL)-6, in patients with TDL with chronic airflow limitation (n=94). We evaluated the correlation of these parameters with acute exacerbation.
Results:We found that patients with exacerbation were more likely to have bronchiectasis than those without exacerbation (patients with exacerbation, 66.7%; patients without exacerbation, 30.5%; P=0.001). CRP and IL-6 levels were significantly higher in patients with exacerbation than in those without exacerbation (P=0.001 and P<0.001, respectively). Bronchiectasis [OR, 3.248; 95% confidence interval (CI), 1.063-9.928; P=0.039] and elevated IL-6 levels (OR, 1.128; 95% CI, 1.013-1.257; P=0.028) were the most important parameters associated with acute exacerbation in patients with TDL with airflow limitation.
Conclusions:Patients with bronchiectasis and high IL-6 levels may require more intensive treatment to prevent acute exacerbation.
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【Elevated interleukin-6 and bronchiectasis as risk factors for acute exacerbation in patients with tuberculosis-destroyed lung with airflow limitation.].
【白细胞介素6和支气管扩张症是患有气流受限的肺结核病患者急性加重的危险因素。】
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DOI：10.21037/jtd.2018.08.29文章类型：杂志文章
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背景：患有肺结核病（TDLs），气流受限的患者具有与慢性阻塞性肺疾病（COPD）患者相似的临床特征。急性加重是控制TDL的重要因素。因此，本研究的目的是调查与气流受限的稳定TDL患者急性加重相关的因素。
方法：我们评估了患有TDL的TDL患者的临床特征，例如肺功能，图像表现和血清实验室表现，包括C反应蛋白（CRP），红细胞沉降率（ESR）和白介素（IL）-6。慢性气流受限（n = 94）。我们评估了这些参数与急性加重的相关性。
结果：我们发现，加重患者比无加重患者更容易患支气管扩张（加重患者为66.7％；无加重患者为30.5％； P = 0.001）。加重患者的CRP和IL-6水平显着高于无加重患者（分别为P = 0.001和P <0.001）。支气管扩张[OR，3.248; 95％置信区间（CI），1.063-9.928； P = 0.039]和升高的IL-6水平（OR，1.128； 95％CI，1.013-1.257； P = 0.028）是与气流受限的TDL患者急性加重相关的最重要参数。
结论：支气管扩张和高IL-6的患者可能需要更深入的治疗，以防止急性加重。
方法：我们评估了患有TDL的TDL患者的临床特征，例如肺功能，图像表现和血清实验室表现，包括C反应蛋白（CRP），红细胞沉降率（ESR）和白介素（IL）-6。慢性气流受限（n = 94）。我们评估了这些参数与急性加重的相关性。
结果：我们发现，加重患者比无加重患者更容易患支气管扩张（加重患者为66.7％；无加重患者为30.5％； P = 0.001）。加重患者的CRP和IL-6水平显着高于无加重患者（分别为P = 0.001和P <0.001）。支气管扩张[OR，3.248; 95％置信区间（CI），1.063-9.928； P = 0.039]和升高的IL-6水平（OR，1.128； 95％CI，1.013-1.257； P = 0.028）是与气流受限的TDL患者急性加重相关的最重要参数。
结论：支气管扩张和高IL-6的患者可能需要更深入的治疗，以防止急性加重。
