AIMS:We aimed to determine whether there is an association between dietary zinc intake (DZI) and prevalent kidney stone disease defined as self-report of any previous episode of kidney stone. METHODS:We examined The Third National Health and Nutrition Examination Survey (NHANES III), a large US population-based cross-sectional study, and used logistic regression analyses to determine the independent association between DZI and prevalent kidney stone disease. RESULTS:A total of 15,444 men and women over 18 years of age were eligible for analysis. Among them, 710 participants reported a history of kidney stones. Stone formers tended to have higher DZI than non-stone formers among NHANES III participants, though this difference did not reach statistical significance (p = 0.1). Multivariate adjusted logistic regression analysis revealed that higher DZI (log transformed) was associated with a significantly increased risk of kidney stone disease (odds ratio, OR = 1.41, 95% confidence interval, CI: 1.10-1.81, p = 0.01). After categorizing zinc intake into three groups, those with highest DZI (>15 mg/day) were also associated with a significantly increased risk of kidney stone disease, compared to those with lower DZI (<7 mg/day; OR = 1.70, 95% CI: 1.13-2.57, p = 0.01). CONCLUSIONS:Our study suggests that higher DZI is associated with increased risk of kidney stone disease. Future prospective studies are needed to clarify the causal relationship between zinc intake and kidney stone formation.

译文

目的:我们旨在确定饮食锌摄入量(DZI)与普遍存在的肾结石疾病之间是否存在关联,该疾病定义为先前发生的任何肾结石自我报告。
方法:我们审查了第三次全国健康和营养检查调查(NHANES III),这是一项基于美国人群的大型横断面研究,并使用Logistic回归分析确定DZI与普遍的肾结石病之间的独立关联。
结果:共有15444名18岁以上的男性和女性符合分析条件。其中,有710名参与者报告了肾结石病史。在NHANES III参与者中,结石形成者的DZI倾向于比非结石形成者高,尽管这种差异没有统计学意义(p = 0.1)。多元校正的logistic回归分析显示,较高的DZI(经对数转换)与肾结石疾病的风险显着增加相关(优势比,OR = 1.41,95%置信区间,CI:1.10-1.81,p = 0.01)。将锌的摄入量分为三组后,与DZI较低(<7 mg /天;或= 1.70,95)相比,DZI最高(> 15毫克/天)的人与肾结石疾病的风险也显着增加。 %CI:1.13-2.57,p = 0.01)。
结论:我们的研究表明,较高的DZI与肾结石疾病的风险增加有关。需要进一步的前瞻性研究来阐明锌摄入量与肾结石形成之间的因果关系。

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