Over the course of its long history, Armenia has acted as both a source of numerous indigenous cultures and as a recipient of foreign invasions. As a result of this complex history among populations, the gene pool of the Armenian population may contain traces of historically well-documented ancient migrations. Furthermore, the regions within the historical boundaries of Armenia possess unique demographic histories, having hosted both autochthonous and specific exogenous genetic influences. In the present study, we analyze the Armenian population sub-structure utilizing 17 Y-chromosome short tandem repeat (Y-STR) loci of 412 Armenians from four geographically and anthropologically well-defined groups (Ararat Valley, Gardman, Lake Van and Sasun). To place the genetic composition of Armenia in a regional and historic context, we have compared the Y-STR profiles from these four Armenian collections to 18 current-day Eurasian populations and two ancient DNA collections. Our results illustrate regional trends in Armenian paternal lineages and locale-specific patterns of affinities with neighboring regions. Additionally, we observe a phylogenetic relationship between the Northern Caucasus and the group from Sasun, which offers an explanation for the genetic divergence of this group from other three Armenian collections. These findings highlight the importance of analyzing both general populations as well as geographically defined sub-populations when utilizing Y-STRs for forensic analyses and population genetics studies.

译文

:在悠久的历史过程中,亚美尼亚既是众多土著文化的发源地,又是外国入侵的接受者。由于人口之间的这种复杂的历史,亚美尼亚人口的基因库可能包含历史上有据可查的古代移民的痕迹。此外,亚美尼亚历史范围内的地区拥有独特的人口历史,既受到了本地遗传的影响,也受到了特定的外源遗传的影响。在本研究中,我们使用来自四个地理和人类学上明确定义的群体(阿拉拉特山谷,加德曼,范湖和萨桑)的412个亚美尼亚人的17个Y染色体短串联重复序列(Y-STR)位点来分析亚美尼亚人口的子结构。 。为了将亚美尼亚的遗传组成放在区域和历史背景下,我们比较了这四个亚美尼亚收藏与18个现今欧亚人口和两个古代DNA收藏的Y-STR图谱。我们的结果说明了亚美尼亚父系血统的区域趋势以及与邻近区域的亲和力的特定于区域的模式。此外,我们观察到北高加索地区与萨桑省的种群之间存在系统发育关系,这为该种群与亚美尼亚其他三个集合的遗传差异提供了解释。这些发现凸显了在使用Y-STRs进行法医分析和人口遗传学研究时,分析一般人群以及地理上定义的亚群的重要性。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录