The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups than in the Sham and OVX Groups, respectively (p<0.001). The animals in the Sham-Est and OVX-Est Groups spent lower time in the target quadrant (Q1) than those of the Sham and OVX Groups during the probe trial test (p<0.05 and <0.001, respectively). Significantly lower nitric oxide metabolite levels in the hippocampi of the Sham-Est and OVX-Est Groups were observed than in the Sham and OVX ones (p<0.001). These results suggest that decreased nitric oxide levels in the hippocampus may play a role in the learning and memory deficits observed after treatment with a high dose of estradiol, although the precise underlying mechanisms remain to be elucidated.

译文

:研究了高雌二醇剂量对海马组织记忆力和一氧化氮代谢产物的影响。 Sham-Est和OVX-Est组分别用4 mg / kg的戊酸雌二醇处理12周。 Sham-Est和OVX-Est组的时间延迟和路径长度分别比Sham和OVX组高(p <0.001)。在探针试验过程中,Sham-Est和OVX-Est组的动物在目标象限(Q1)上花费的时间比Sham和OVX组的动物低(分别为p <0.05和<0.001)。与Sham和OVX组相比,Sham-Est和OVX-Est组海马中的一氧化氮代谢产物水平显着降低(p <0.001)。这些结果表明,海马中一氧化氮水平的下降可能在大剂量雌二醇治疗后观察到的学习和记忆障碍中起作用,尽管确切的潜在机制尚待阐明。

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