In the first experiment castrated male rats were injected daily with either vehicle or 800 mug testosterone together with either 6 hr pretreatment or concurrent treatment with the anti-estrogens CI-628 (4 mg) or MER-25 (20 mg). The only treatment found to significantly reduce male copulatory behavior was concurrent treatment with CI-628. Anti-estrogen treatment was also found to slightly reduce body weights, increase seminal vesicle weights in response to testosterone and to have no significant effects on androgen stimulated increases in penis weight and length. In the second experiment castrated male rats were injected daily with either vehicle or 500 mug testosterone together with 2.5 mg injections of CI-628 given 6 hr before and concurrent with the androgen injections. The anti-estrogen treatment was found to markedly inhibit the desplay of male sexual behavior, to reduce body weights, and to stimulate seminal vesicle weights. Penile weights and lengths were again not effected by the anti-estrogen therapy. These results were interpreted as supporting the theory that testosterone stimulated male sexual behavior in the rat following its aromatization to estradiol in the brain.

译文

在第一个实验中,daily割的雄性大鼠每天注射媒介物或800杯睾丸激素,同时进行6小时的预处理或同时使用抗雌激素CI-628(4 mg)或MER-25(20 mg)进行注射。发现唯一能显着降低男性交配行为的治疗方法是同时进行CI-628治疗。还发现抗雌激素治疗可略微减轻体重,响应睾丸激素增加精囊重量,并且对雄激素刺激的阴茎重量和长度增加没有显着影响。在第二个实验中,daily割的雄性大鼠每天在雄激素注射前6个小时同时注射媒介物或500杯睾丸激素以及2.5毫克CI-628注射剂。发现抗雌激素治疗可显着抑制男性性行为的淡化,减轻体重和刺激精囊重量。阴茎的重量和长度也不受抗雌激素疗法的影响。这些结果被解释为支持以下理论的观点:睾丸激素在芳香化为大脑中的雌二醇后会刺激大鼠的男性性行为。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录