Chronic administration of nadolol has been reported to reduce blood pressure either without or with a concomitant fall of renal blood flow. We therefore studied the effects of nadolol 80 mg once daily on ambulatory blood pressure, renal and systemic haemodynamics in patients with mild to moderate essential hypertension. Ten patients took part in this randomized, double-blind, placebo-controlled, crossover study, each phase of which lasted 4 weeks. Nadolol significantly reduced ambulatory blood pressure and heart rate, but had no effect on blood pressure variability. Cardiac output was significantly reduced by nadolol and total peripheral resistance increased but without reaching statistical significance. Despite the fall in blood pressure and cardiac output, renal blood flow and glomerular filtration rate remained unchanged. The fraction of cardiac output reaching the kidneys rose significantly and renal vascular resistance was significantly reduced. Body weight, urinary sodium excretion and urine flow rate remained unchanged. We conclude that nadolol 80 mg once daily lowers ambulatory blood pressure in patients with mild to moderate hypertension without impairment of renal blood flow, indicating a redistribution of cardiac output to the kidneys. The mechanism of the renal vasodilator effect of nadolol remains to be determined.

译文

:有报道称,长期服用萘多洛可降低血压,既不伴有肾血流下降,也可伴有肾血流下降。因此,我们研究了纳多洛尔80 mg每天一次对轻度至中度原发性高血压患者动态血压,肾脏和全身血流动力学的影响。十名患者参加了这项随机,双盲,安慰剂对照,交叉研究,其每个阶段持续4周。纳多洛尔显着降低了门诊血压和心率,但对血压变异性没有影响。萘多洛尔可显着降低心输出量,总外周阻力增加,但未达到统计学意义。尽管血压和心输出量下降,但肾血流量和肾小球滤过率保持不变。到达肾脏的心输出量比例显着上升,肾血管阻力显着降低。体重,尿钠排泄和尿流率保持不变。我们得出的结论是,纳多洛尔80 mg每天一次可降低轻度至中度高血压患者的门诊血压,而不会损害肾血流量,这表明心输出量会重新分配给肾脏。纳多洛尔的肾血管舒张作用机制尚待确定。

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