The role of the thyroid gland in glucose homeostasis remains incompletely understood. To get a better insight hypo-and hyperthyroid conditions were experimentally induced in rat and found severe defects in glucose homeostasis. While blood glucose level returned to normal level after 2.5 hr of oral glucose challenge in control rats the blood glucose level remained high even after 24 hr of glucose load in both hypo- and hyperthyroid rats. These experimentally manipulated rats displayed higher levels of liver glycogen (10.45-22.8-fold) and serum glutamic pyruvic transaminase (1.48-9.8-fold). Liver histology of hyperthyroid treated rats revealed hepatotoxicity. From the results it can be concluded that thyroid gland plays an important role in glucose homeostasis.

译文

:甲状腺在葡萄糖稳态中的作用仍未完全了解。为了更好地了解大鼠的甲状腺功能低下和甲状腺功能亢进症,并发现其体内葡萄糖稳态严重缺陷。在对照组大鼠口服葡萄糖2.5小时后血糖水平恢复到正常水平时,即使在甲状腺功能减退和甲状腺功能亢进的大鼠中,即使在葡萄糖加载24小时后,血糖水平仍保持较高水平。这些实验操作的大鼠显示出较高水平的肝糖原(10.45-22.8倍)和血清谷氨酸丙酮酸转氨酶(1.48-9.8倍)。甲亢治疗大鼠的肝脏组织学显示肝毒性。从结果可以得出结论,甲状腺在葡萄糖稳态中起重要作用。

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