In mammals, profound changes in the population and functions of adult stem cells occur with age and these changes are thought to underlie functional decline and pathophysiology at the tissue and organismal levels associated with aging. SIRT1, a member of the conserved sirtuin family, functions as an anti-aging regulator for adult stem cells. Mediated through its regulatory roles in AMPK and mTORC1 pathways as well as gene expression, SIRT1 modulate the activities of genes maintaining stem cell functions and delays cellular senescence. Further investigation of the cross-talk between SIRT1 and other longevity target genes under different physiological conditions of stem cells may help us better design intervention strategies to antagonize stem cells aging.

译文

:在哺乳动物中,成年干细胞的数量和功能随着年龄的增长而发生深刻变化,这些变化被认为是与衰老相关的组织和机体水平的功能下降和病理生理的基础。 SIRT1是sirtuin保守家族的成员,可作为成人干细胞的抗衰老调节剂。通过其在AMPK和mTORC1途径以及基因表达中的调控作用介导,SIRT1调节维持干细胞功能并延缓细胞衰老的基因活性。进一步研究SIRT1与其他寿命目标基因在干细胞不同生理条件下的串扰可能有助于我们更好地设计干预策略,以对抗干细胞衰老。

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