The in vitro antibacterial activity of two agents relatively resistant to beta-lactamases, BL-S786 and cefoxitin, was tested against 123 recent different clinical isolates of cephalothin-resistant Enterobacteriaceae. BL-S786 showed considerable activity against Escherichia coli and lesser activity against Klebsiella pneumoniae with, respectively, 68% and 41% inhibited at 32 microng/ml. Cefoxitin showed more activity in vitro against E. coli, K. pneumoniae, Serratia marcescens and Providencia stuartii. Cefoxitin appears to be a more promising agent for treating infections caused by cephalothin-resistant Enterobacteriaceae.

译文

:对β-内酰胺酶(BL-S786和头孢西丁)具有相对抗性的两种药物的体外抗菌活性已针对头孢菌素抗性肠杆菌科的123种近期不同临床分离株进行了测试。 BL-S786对大肠杆菌表现出相当大的活​​性,对肺炎克雷伯菌的活性较小,分别以32 microng / ml抑制了68%和41%。头孢西丁在体外显示出对大肠杆菌,肺炎克雷伯菌,粘质沙雷氏菌和斯氏普罗维登斯氏菌的更多活性。头孢西丁似乎是治疗由头孢菌素耐药性肠杆菌科细菌引起的感染的更有前途的药物。

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