OBJECTIVES:The study objectives were to estimate the prevalence of chronic diseases and other health indicators for Hispanics in Missouri, and to compare their prevalence estimates with other racial/ethnic groups. DESIGN / SETTING / PARTICIPANTS: This study, conducted in public health and academic settings, used combined data from the 2002 and 2003 Missouri Behavioral Risk Factor Surveillance System and the 2003 Missouri County-Level Study. Data were post-stratified with Hispanic ethnicity as a separate group. MAIN OUTCOME MEASURES:Twenty health indicators were compared. Logistic regression was used to control for sociodemographic characteristics. RESULTS:Overall, 21.7% (95% confidence interval [CI] 13.4-30.0) of Hispanics, 19.8% (95% CI 14.4-25.2%) of non-Hispanic Blacks, and 12.2% (95% CI 11.2-13.1%) of non-Hispanic Whites had no insurance coverage. Hispanics were significantly less likely to report poor or fair health (12.1%, 95% CI 7.5-16.7%) than non-Hispanic Blacks (21.6%, 95% CI 17.2-26.0%), and less likely to report activity limitation (12.9%, 95% CI 8.0-17.9%) than non-Hispanic Whites (20.2%, 95% CI 19.1-21.2%). Controlling for sociodemographic characteristics, Hispanics had greater physician-diagnosed diabetes (OR = 2.0, 95% CI 1.0-3.3%) and Hispanics aged > or = 50 were less likely to have no sigmoidoscopy or colonoscopy in the past five years (OR = 0.5, 95% CI 0.2-1.0%) compared to non-Hispanic Whites. CONCLUSIONS:Other than lower healthcare coverage and diabetes status, the health indicators for English-speaking Hispanics were similar to, or better than, non-Hispanic Blacks and Whites. However, these data may not represent all Hispanics in Missouri since health status between English-speaking and non-English speaking Hispanics may differ significantly.