The objective of the study was to evaluate the association between peripheral venous disease (PVD) and arterial endothelial dysfunction (ED). Arterial and venous diseases have been always considered as two completely different entities, but the recent discovery of a relationship between arterial and venous thrombosis have challenged this assumption. ED, considered to be an early process in the pathophysiology of atherosclerotic disease, could represent a common pathogenetic background. We studied 39 healthy volunteers (median age: 34 years; men: 25.6%). PVD was diagnosed using ultrasound examination, arterial ED using flow-mediated dilation (FMD) and FMD normalized for the peak shear rate (nFMD). Compared with controls, participants with PVD had a lower FMD (15.2 versus 23.4%, P < 0.001) and nFMD (12.7 × 10(-3) versus 19 × 10(-3)/second, P < 0.001). People with the most clinically evident disease had the worst endothelial function. In conclusion, our findings, if confirmed in larger population, might corroborate the idea that venous and arterial disease could have common causes.

译文

:该研究的目的是评估周围静脉疾病(PVD)与动脉内皮功能障碍(ED)之间的关联。动脉和静脉疾病一直被认为是两个完全不同的实体,但是最近发现动脉和静脉血栓形成之间的关系挑战了这一假设。 ED被认为是动脉粥样硬化疾病病理生理的早期过程,可能代表了常见的致病背景。我们研究了39名健康志愿者(中位年龄:34岁;男性:25.6%)。使用超声检查诊断PVD,使用流介导的扩张(FMD)诊断动脉ED,并针对峰剪切速率(nFMD)归一化FMD。与对照组相比,PVD参与者的FMD较低(15.2比23.4%,P <0.001)和nFMD(12.7×10(-3)/ 19×10(-3)/秒,P <0.001)。临床上最明显的疾病的人的内皮功能最差。总之,我们的发现,如果在更大的人群中得到证实,可能证实静脉和动脉疾病可能是常见原因的观点。

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