Considerable work still needs to be done to understand more fully the basic processes going on inside the non-photosynthetic plastid organelle of Plasmodium spp., the causative agent of malaria. Following an explosion of genomic and transcriptional information in recent years, research workers are still analysing these data looking for new material relevant to the plastid. Several metabolic and housekeeping functions based on bacterial biochemistry have been elucidated and this has given impetus to finding lead inhibitors based on established anti-microbials. Structural investigations of plastid-associated enzymes identified as potential targets have begun. This review gives a perspective on the research to date and hopes to emphasize that a practical outcome for the clinic should be an important focus of future efforts. Malaria parasites have become resistant to front-line anti-malarials that are widely used and were formerly dependable. This has become a worrying problem in many regions where malaria is endemic. The time lag between hunting for new inhibitors and their application as pharmaceuticals is so long and costly that a steady stream of new ventures has to be undertaken to give a reasonable chance of finding affordable and appropriate anti-malarials for the future. Attempts to find inhibitors of the plastid organelle of the malaria parasite should be intensified in such programmes.

译文

:仍需要做大量工作以更充分地了解疟疾的致病性疟原虫的非光合质体细胞器内部的基本过程。近年来,随着基因组和转录信息的爆炸式增长,研究人员仍在分析这些数据,以寻找与质体相关的新材料。阐明了基于细菌生物化学的几种代谢和内务处理功能,这推动了基于既定抗微生物剂的铅抑制剂的发现。被鉴定为潜在靶标的质体相关酶的结构研究已经开始。这篇综述为迄今为止的研究提供了一个观点,并希望强调临床的实际结果应该是未来工作的重要重点。疟原虫已经对一线抗疟疾产生了抵抗力,这些抗疟疾被广泛使用并且以前是可靠的。在疟疾流行的许多地区,这已成为令人担忧的问题。寻找新抑制剂与将其用作药物之间的时间间隔太长且成本高昂,因此必须进行源源不断的新投资,才能有合理的机会为将来找到负担得起且合适的抗疟药。在此类计划中应加强寻找疟原虫质体细胞器抑制剂的尝试。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录