The spread of dengue virus (DV) via its Aedes mosquito vector throughout most of the tropics has led to a worldwide resurgence of epidemic dengue, including dengue hemorrhagic fever. For the first time in 60 years, the pipeline of dengue vaccines looks promising. Strains of each of the 4 DV serotypes, attenuated by passage in tissue culture or by recombinant DNA technology, have been formulated into tetravalent vaccines and have entered successful phase 1 and 2 clinical trials in the United States and Southeast Asia. Antibody-dependent enhancement of wild-type DV infections by the vaccine represents a unique safety issue, which is under investigation. The Pediatric Dengue Vaccine Initiative (funded by the Bill and Melinda Gates Foundation), the World Health Organization, industry, the US military, and governments of tropical countries are collaborating to accelerate dengue vaccine development and phase 3 vaccine efficacy trials in countries where dengue is endemic. A protective tetravalent vaccine must be licensed soon if dengue is to be brought under control.

译文

:登革热病毒(DV)通过其伊蚊(Aedes)蚊子传播到整个热带大部分地区,导致登革热在全球范围内重新流行,包括登革热出血热。 60年来,登革热疫苗的首次面世前景看好。通过在组织培养中传代或通过重组DNA技术减毒的4种DV血清型中的每一种菌株已配制成四价疫苗,并已在美国和东南亚成功进入1和2期临床试验。疫苗对野生型DV感染的抗体依赖性增强代表了一个独特的安全问题,正在研究中。儿科登革热疫苗行动计划(由比尔和梅琳达·盖茨基金会资助),世界卫生组织,工业界,美国军方和热带国家政府正在合作,以加快登革热所在国家的登革热疫苗开发和3期疫苗功效试验地方性的。如果要控制登革热,必须尽快获得保护性四价疫苗的许可。

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