OBJECTIVE:The objective of the study was to assess depressive symptoms (DS) and difficulties in emotion regulation (ER) in adult people with epilepsy (PWE) and their correlation with quality of life and stigmatization feelings of patients. MATERIALS AND METHODS:We enrolled consecutively 110 PWE who completed the Beck Depression Inventory-II (BDI-II) questionnaire and, for the first time, the Italian translation of Difficulties in Emotion Regulation Scale (DERS) to evaluate DS and ER. They also fulfilled the Italian version of the Stigma Scale of Epilepsy (SSE), which allowed the quantification of the stigma perception by our cohort of patients and a 3-item Jacoby's Stigma Scale (JSS) and QOLIE-31 (Q31) for the evaluation of stigma and the quality of life. The results of BDI-II and DERS were correlated with clinical details of PWE, as well as the Q31 and SSE scores. Finally, a multiple stepwise regression analysis was applied to identify the main factors affecting DS and ER difficulties in these patients. RESULTS:About 30% of PWE evidenced DS, of which 17.3% showed a BDI-II score higher than 19, suggestive of moderate to severe DS. Several factors related to epilepsy (seizure frequency, number of antiepileptic drugs (AEDs)) as well as ER and quality of life/stigmatization perception resulted significantly correlated with DS. As a new finding, the main factors affecting DS in PWE turned out to be the difficulties in ER and quality of life and stigma perception (as evaluated through Q31 and JSS scores). CONCLUSIONS:Our findings evidenced that DS in PWE are highly prevalent and strongly correlated with ER difficulties that mostly influence DS together with quality of life and stigma perception. Depressive symptoms and emotion dysregulation are linked by a bidirectional relationship and are significantly associated with worse quality of life and higher stigmatization feelings.

译文

目的:本研究的目的是评估成人癫痫病患者(PWE)的抑郁症状(DS)和情绪调节困难(ER)及其与患者生活质量和耻辱感的相关性。
材料与方法:我们连续招募了110名PWE,他们完成了贝克抑郁量表II(BDI-II)问卷调查,并首次用意大利语翻译了《情绪调节量表的难点》(DERS)以评估DS和ER。他们还满足了意大利语版本的癫痫柱头量表(SSE),该标准允许我们的患者队列对柱头知觉的量化,并使用3个项目的Jacoby柱头量表(JSS)和QOLIE-31(Q31)进行评估。的污名和生活质量。 BDI-II和DERS的结果与PWE的临床细节以及Q31和SSE得分相关。最后,应用多元逐步回归分析来确定影响这些患者DS和ER困难的主要因素。
结果:约有30%的PWE证据表明DS,其中17.3%的BDI-II评分高于19,表明中度至重度DS。与癫痫有关的几个因素(癫痫发作频率,抗癫痫药物(AED)的数量)以及内质网和生活质量/耻辱感与DS有关。作为一项新发现,影响PWE中DS的主要因素原来是ER的困难以及生活质量和柱头感(通过Q31和JSS得分评估)。
结论:我们的研究结果表明,PWE中的DS十分普遍,并且与ER困难密切相关,而ER困难主要影响DS以及生活质量和耻辱感。抑郁症状和情绪失调之间存在双向关系,并与生活质量较差和污名化感较高相关。

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