BACKGROUND:Difficulties in emotion regulation and craving regulation have been linked to eating symptomatology in patients with anorexia nervosa (AN), contributing to the maintenance of their eating disorder. METHODS:To investigate clinical and electrophysiological correlates of these processes, 20 patients with AN and 20 healthy controls (HC) completed a computerized task during EEG recording, where they were instructed to down-regulate negative emotions or food craving. Participants also completed self-report measures of emotional regulation and food addiction. The P300 and Late Positive Potential (LPP) ERPs were analysed. RESULTS:LPP amplitudes were significantly smaller during down-regulation of food craving among both groups. Independent of task condition, individuals with AN showed smaller P300 amplitudes compared to HC. Among HC, the self-reported use of re-appraisal strategies positively correlated with LPP amplitudes during emotional regulation task, while suppressive strategies negatively correlated with LPP amplitudes. The AN group, in comparison to the HC group, exhibited greater food addiction, greater use of maladaptive strategies, and emotional dysregulation. CONCLUSIONS:Despite the enhanced self-reported psychopathology among AN, both groups indicated neurophysiological evidence of food craving regulation as evidenced by blunted LPP amplitudes in the relevant task condition. Further research is required to delineate the mechanisms associated with reduced overall P300 amplitudes among individuals with AN.

译文

背景:情绪调节和渴望调节的困难与神经性厌食症(AN)患者的饮食症状有关,有助于维持其饮食失调。
方法:为调查这些过程的临床和电生理相关性,在脑电图记录期间,有20位AN患者和20位健康对照(HC)完成了计算机化任务,并指示他们下调负面情绪或对食物的渴望。参与者还完成了情绪调节和食物成瘾的自我报告措施。分析了P300和后期正电位(LPP)ERP。
结果:两组间食物渴望的下调过程中,LPP幅度均显着较小。与任务条件无关,与HC相比,AN患者的P300振幅更小。在HC中,自我报告的重新评估策略的使用在情绪调节任务中与LPP幅度呈正相关,而抑制策略与LPP幅度呈负相关。与HC组相比,AN组表现出更多的食物成瘾,更多的不良适应策略和情绪失调。
结论:尽管AN之间自我报告的精神病理学增强,但两组均显示出对食物渴望调节的神经生理学证据,在相关工作条件下LPP幅度变钝来证明。需要进一步的研究来描述与AN患者个体P300总振幅降低有关的机制。

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