Functional MRI studies report insular activations across a wide range of tasks involving affective, sensory, and motor processing, but also during tasks of high-level perception, attention, and control. Although insular cortical activations are often reported in the literature, the diverse functional roles of this region are still not well understood. We used a meta-analytic approach to analyze the coactivation profiles of insular subdivisions-dorsal anterior, ventral anterior, and posterior insula-across fMRI studies in terms of multiple task domains including emotion, memory, attention, and reasoning. We found extensive coactivation of each insular subdivision, with substantial overlap between coactivation partners for each subdivision. Functional fingerprint analyses revealed that all subdivisions cooperated with a functionally diverse set of regions. Graph-theoretical analyses revealed that the dorsal anterior insula was a highly "central" structure in the coactivation network. Furthermore, analysis of the studies that activate the insular cortex itself showed that the right dorsal anterior insula was a particularly "diverse" structure in that it was likely to be active across multiple task domains. These results highlight the nuanced functional profiles of insular subdivisions and are consistent with recent work suggesting that the dorsal anterior insula can be considered a critical functional hub in the human brain.

译文

:功能性MRI研究报告了在涉及情感,感觉和运动处理以及高水平感知,注意力和控制任务的广泛任务中的岛状激活。尽管岛上皮层激活经常在文献中报道,但对该区域的各种功能作用仍知之甚少。我们使用荟萃分析方法,通过多个任务域,包括情感,记忆,注意力和推理,分析了岛状区—背侧前,腹侧前和背侧岛上的功能磁共振成像研究的共激活特征。我们发现每个岛细分广泛的共激活,每个细分的共激活伙伴之间存在实质性重叠。功能指纹分析表明,所有细分区域均与功能多样的区域协作。图论分析表明,背侧前岛岛在共激活网络中是高度“中心”的结构。此外,对激活岛状皮层本身的研究的分析表明,右背前岛岛是一种特别的“多样化”结构,因为它可能在多个任务域中活跃。这些结果突出了岛状细分的细微功能分布,并与最近的工作一致,表明背侧前岛绝缘可被认为是人脑的关键功能枢纽。

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