BACKGROUND:Differentiating stroke due to Trousseau's syndrome from other types of cerebral embolism is challenging, especially in patients with occult cancer. The current study aimed to determine predicting factors and biomarkers of stroke due to Trousseau's syndrome. METHODS:This retrospective study comprised 496 consecutive patients with acute cerebral embolism, including 19, 85, 310, and, 82 patients with stroke due to Trousseau's syndrome, artery-to-artery embolism, cardioembolic stroke, and embolic stroke with undetermined source, respectively. All patients were evaluated within 72 hours of onset. The clinical characteristics, laboratory findings, and patterns on diffusion-weighted magnetic resonance imaging (DWI) were compared among the groups. RESULTS:Plasma D-dimer and C-reactive protein (CRP) levels were significantly higher in the Trousseau's syndrome than in the other causes of cerebral embolism. Multivariate analyses demonstrated that female sex, multiple lesions on DWI, high D-dimer and CRP levels, and low platelet and low brain natriuretic peptide levels were independent predictors that could distinguish Trousseau's syndrome from the other causes of cerebral embolism. The cutoff values of D-dimer and CRP to identify stroke due to Trousseau's syndrome was 2.68 µg/mL fibrinogen equivalent units and .29 mg/dL, respectively. CONCLUSIONS:The elevated D-dimer and CRP levels on admission in addition to specific clinical features may be useful for diagnosis of Trousseau's syndrome in patients with cerebral embolism.

译文

背景:特鲁索综合症引起的中风与其他类型的脑栓塞的区别是具有挑战性的,特别是在隐匿性癌症患者中。当前的研究旨在确定特鲁索综合症所致中风的预测因素和生物标志物。
方法:这项回顾性研究包括496例连续的急性脑栓塞患者,包括19例,85例,310例和82例因Trousseau综合征而患中风,动脉-动脉栓塞,心栓性中风和栓塞性中风的来源不明。 。所有患者在发病72小时内进行了评估。比较各组的临床特征,实验室检查结果和弥散加权磁共振成像(DWI)的模式。
结果:Trousseau综合征的血浆D-二聚体和C反应蛋白(CRP)水平显着高于其他原因的脑栓塞。多变量分析表明,女性,DWI的多个病变,D-二聚体和CRP含量高,血小板和脑钠肽含量低是独立的预测因素,可以将Trousseau综合征与其他脑栓塞原因区分开。 D-二聚体和CRP识别Trousseau综合征所致中风的临界值分别为2.68 µg / mL纤维蛋白原当量单位和0.29 mg / dL。
结论:入院时D-二聚体和CRP水平升高,除了具有特定的临床特征外,可能有助于诊断脑栓塞患者的特鲁索综合症。

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