PURPOSE:Obesity has emerged as one of the biggest health crisis and is the leading cause of death and disabilities around the world. BMI trends suggest that majority of the increase in T2D is resulting from the increased prevalence of obesity. In fact, 85.2% of people with T2D are overweight or obese. The highest prevalence for obesity is seen in non-Hispanic, African American women (56.6%). T2D is classified as an inflammatory disease because of elevated, circulating pro-inflammatory cytokines and acute-phase inflammatory proteins. This study was designed to determine how high HbA1c and serum glucose correlate with circulatory cytokine levels in obese, African American women. METHODS:We investigated cytokine/chemokine serum levels using a multiplex assay. Then we used Pairwise Pearson Correlation Test to determine the relationship between clinical metabolic parameters and cytokine/chemokine serum levels. RESULTS:The results indicated that participants with elevated HbA1c exhibited an up regulation of IL-3, IL-4, IL-7, TNF-α, IFN-α2 and CX3CL1 serum levels compared to participants with normal HbA1c. These cytokines were also correlated with several clinical metabolic parameters. CONCLUSIONS:The results suggest that IL-3, IL-4, IL-7, TNF-α, IFN-α2 and CX3CL1 serum levels may contribute to the development and onset of type 2 diabetes.

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目的:肥胖已经成为最大的健康危机之一,并且是导致世界范围内死亡和残疾的主要原因。 BMI趋势表明,T2D的增加大部分是由肥胖症患病率增加引起的。实际上,患有T2D的人中有85.2%是超重或肥胖。在非西班牙裔非裔美国女性中,肥胖发生率最高(56.6%)。由于升高的循环中的促炎细胞因子和急性期炎性蛋白,T2D被归类为炎性疾病。这项研究的目的是确定肥胖的非洲裔美国女性中高水平的HbA1c和血清葡萄糖与循环细胞因子水平的相关性。
方法:我们使用多重分析研究了细胞因子/趋化因子的血清水平。然后,我们使用成对皮尔逊相关检验确定临床代谢参数与细胞因子/趋化因子血清水平之间的关系。
结果:与正常HbA1c参与者相比,HbA1c升高的参与者表现出IL-3,IL-4,IL-7,TNF-α,IFN-α2和CX3CL1血清水平的上调。这些细胞因子也与几种临床代谢参数相关。
结论:结果提示IL-3,IL-4,IL-7,TNF-α,IFN-α2和CX3CL1血清水平可能与2型糖尿病的发生和发作有关。

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