BACKGROUND:Chemotherapy and intensity-modulated radiotherapy (IMRT) have decreased treatment-related complications in adult patients with nasopharyngeal carcinoma (NPC). Our aim was to evaluate the toxicity profile of IMRT plus chemotherapy in pediatric NPC patients. OBSERVATIONS:Five patients were treated with chemotherapy and IMRT. All patients experienced grade 3-4 acute toxicities. With a median follow-up of 6.3 years, all patients experienced >or=3 long-term toxicities. The most common toxicities were hypothyroidism, xerostomia, hearing loss, and dental disease. CONCLUSIONS:We did not observe a significant decrease in long-term toxicities with IMRT plus chemotherapy in our small cohort of pediatric NPC patients.

译文

背景:化学疗法和调强放射疗法(IMRT)减少了成人鼻咽癌(NPC)患者的治疗相关并发症。我们的目的是评估IMRT联合化疗对小儿NPC患者的毒性。
观察:5例患者接受了化疗和IMRT治疗。所有患者均经历3-4级急性毒性。中位随访时间为6.3年,所有患者均经历了≥3的长期毒性。最常见的毒性是甲状腺功能减退,口干,听力下降和牙齿疾病。
结论:在我们的小儿NPC患者队列中,我们未观察到IMRT加化疗的长期毒性显着降低。

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