A mixture of low-molecular-weight poly(L-lactide-co-glycolide ethylene oxide fumarate) (PLGEOF) macromer and high-molecular-weight poly(lactide-co-glycolide) (PLGA) was used to produce fibers by electrospinning. PLGEOF is a biodegradable and in situ cross-linkable terpolymer made from building blocks with excellent biocompatibility. PLGA provides the required elongational viscosity to the spinning jet while the unsaturated PLGEOF macromers contribute to in situ crosslinking of fibers and attachment of bioactive functional groups. Mechanical rheometry demonstrated that PLGEOF macromers cross-link in situ by ultraviolet radiation. The addition of PLGEOF macromer to PLGA solutions had a significant effect on size and morphology of the electrospun fibers. The morphology of the electrospun fibers changed from bead- to fiber-like with increasing PLGEOF concentration. As PLGEOF was added to 12 wt% PLGA solutions, the fiber diameter first decreased with 2% PLGEOF and then increased with the addition of 5% and 10% PLGEOF. Our results demonstrate that the fiber size initially is decreased with the addition of PLGEOF due to an increase in solution conductivity and then is increased with further PLGEOF addition due to higher viscosity of the polymerizing mixture.

译文

:使用低分子量聚(L-丙交酯-乙交酯-环氧乙烷富马酸酯)(PLGEOF)大分子单体和高分子量聚(丙交酯-乙交酯)(PLGA)的混合物通过静电纺丝生产纤维。 PLGEOF是由具有出色生物相容性的结构单元制成的可生物降解的原位可交联三元共聚物。 PLGA向纺丝喷嘴提供所需的伸长粘度,而不饱和PLGEOF大分子单体则有助于纤维的原位交联和生物活性官能团的附着。机械流变学证明PLGEOF大分子单体通过紫外线辐射原位交联。将PLGEOF大分子单体添加到PLGA溶液中对电纺纤维的尺寸和形态有重大影响。随着PLGEOF浓度的增加,电纺纤维的形态从珠状变为类纤维。当将PLGEOF添加到12 wt%PLGA溶液中时,纤维直径首先在2%PLGEOF下减小,然后在添加5%和10%PLGEOF时增大。我们的结果表明,由于溶液电导率的增加,纤维尺寸最初随着添加PLGEOF而减小,然后由于聚合混合物的较高粘度而随着进一步PLGEOF添加而增大。

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