In this work, water-resistant poly (vinyl alcohol) (PVA)/poly (acrylic acid) (PAA) electrospun fibers encapsulating tangeretin (Tan) were fabricated by emulsion-electrospinning. To optimize the electrospinning condition, the size and morphology of electrospun fibers were characterized by dynamic light scattering (DLS), optical light microscope, fluorescence microscopy, and scanning electron microscopy (SEM), respectively. The optimized initial concentration of PVA/PAA was 10% (w/w) with a mass ratio of 3:7. The time and temperature of optimized thermal crosslinking treatment were 2 h and 145 °C, respectively. The results of XRD and SEM showed that the Tan was successfully incorporated into smooth PVA/PAA electrospun fibers and those fibers possessed nano-diameter size and high porosity. The encapsulation of Tan had no significant impact on the antioxidant activity of PVA/PAA/Tan crosslinking electrospun fibers. The in vitro release test showed the PVA/PAA/Tan crosslinking electrospun fibers achieved durable release profiles and lower burst release rates than that from the pure Tan emulsion. Based on these results, it is concluded that PVA/PAA/Tan crosslinking electrospun fibers prepared by emulsion-electrospinning serve as a promising technique in the fields of water-insoluble drug delivery and slow-release.

译文

:在这项工作中,通过乳液静电纺丝制备了包裹橘皮素(Tan)的耐水聚乙烯醇(PVA)/聚丙烯酸(PAA)电纺纤维。为了优化电纺条件,分别通过动态光散射(DLS),光学显微镜,荧光显微镜和扫描电子显微镜(SEM)对电纺纤维的尺寸和形态进行了表征。 PVA / PAA的最佳初始浓度为10%(w / w),质量比为3:7。优化的热交联处理的时间和温度分别为2 h和145°C。 XRD和SEM的结果表明,Tan成功地掺入了光滑的PVA / PAA电纺纤维中,并且这些纤维具有纳米直径的尺寸和高孔隙率。 Tan的包封对PVA / PAA / Tan交联电纺纤维的抗氧化活性没有明显影响。体外释放测试表明,与纯棕褐色乳液相比,PVA / PAA / Tan交联电纺纤维具有持久的释放特性和较低的破裂释放速率。基于这些结果,得出结论,通过乳液电纺丝制备的PVA / PAA / Tan交联电纺纤维在水不溶性药物递送和缓释领域中是有前途的技术。

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