Dextran is soluble in both water and organic solvents, so it could be a versatile biomacromolecule for preparing nanofibrous electrospun membranes by blending with either water-soluble bioactive agents or hydrophobic biodegradable polymers for biomedical applications. We have formulated electrospun dextran membranes, and the effects of various processing parameters on the membrane properties were investigated. It was found that uniform nanofibrous dextran membranes could be formed by using water, DMSO/water, and DMSO/DMF mixtures as solvents through adjusting the processing conditions (solution concentration, voltage, and the distance between the electrode and the collecting plate). When water was used as a solvent, up to 10% (w/w) of bovine serum albumin (BSA) or lysozyme could be directly incorporated into the dextran electrospun membrane without compromising its morphology. No significant effect of the electrospinning process on lysozyme activity was observed. The composite electrospun membranes consisting of poly(D,L-lactide-co-glycolide) (PLGA) and dextran were obtained using DMSO/DMF (50/50, volume ratio) mixture as solvents. For cross-linking the electrospun membrane, dextran was modified by substitution of methacrylate groups at the hydroxyl sites. It was found that the electrospun membranes prepared from methacrylated dextran can be cured by UV irradiation in the presence of 1% of 2,2-dimethoxy-2-phenylacetophenone (DMPA) as a photoinitiator.

译文

:Dextran可溶于水和有机溶剂,因此通过与水溶性生物活性剂或疏水性可生物降解的聚合物共混用于生物医学应用,它可以成为制备纳米纤维电纺膜的多功能生物大分子。我们配制了静电纺丝的右旋糖酐膜,并研究了各种工艺参数对膜性能的影响。已经发现,通过调节处理条件(溶液浓度,电压以及电极与集电板之间的距离),以水,DMSO /水和DMSO / DMF混合物为溶剂可以形成均匀的纳米纤维葡聚糖膜。当使用水作为溶剂时,可以将不超过10%(w / w)的牛血清白蛋白(BSA)或溶菌酶直接掺入葡聚糖电纺膜中,而不会影响其形态。没有观察到静电纺丝过程对溶菌酶活性的显着影响。使用DMSO / DMF(50/50,体积比)混合物作为溶剂,获得由聚(D,L-丙交酯-共-乙交酯)(PLGA)和右旋糖酐组成的复合电纺膜。为了使电纺膜交联,通过在羟基位点取代甲基丙烯酸酯基团对葡聚糖进行改性。发现由甲基丙烯酸酯化的葡聚糖制备的电纺膜可以在1%的2,2-二甲氧基-2-苯基苯乙酮(DMPA)作为光引发剂存在下通过UV辐射固化。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录