AIM:Despite the substantial progress that has been achieved in interventional cardiology and cardiac electrophysiology, endovascular intervention for the diagnosis and treatment of central nervous system (CNS) disorders such as stroke, epilepsy and CNS malignancy is still limited, particularly due to highly tortuous nature of the cerebral arterial and venous system. Existing interventional devices and techniques enable only limited and complicated access especially into intra-cerebral vessels. The aim of this study was to develop a micro-catheter magnetically-guided technology specifically designed for endovascular intervention and mapping in deep CNS vascular structures. METHODS:Mapping of electrical brain activity was performed via the venous system on an animal dog model with the support of the NIOBE II system. RESULTS:A novel micro-catheter specially designed for endovascular interventions in the CNS, with the support of the NIOBE II technology, was able to reach safely deep intra-cerebral venous structures and map the electrical activity there. Such structures are not currently accessible using standard catheters. CONCLUSION:This is the first study demonstrating successful use of a new micro-catheter in combination with NIOBE II technology for endovascular intervention in the brain.

译文

目的:尽管在介入心脏病学和心脏电生理方面取得了重大进展,但用于中风,癫痫和中枢神经系统恶性肿瘤等中枢神经系统疾病(CNS)疾病的诊断和治疗的血管内干预仍然受到限制,特别是由于高度曲折性脑动脉和静脉系统。现有的介入设备和技术仅允许有限且复杂的通路,尤其是进入脑内血管的通路。这项研究的目的是开发一种微导管磁导技术,专门用于深层中枢神经系统血管结构的血管内介入和标测。
方法:在NIOBE II系统的支持下,通过静脉系统对动物狗模型进行脑电活动测绘。
结果:在NIOBE II技术的支持下,专为中枢神经系统血管内干预而设计的新型微型导管能够安全到达深部脑内静脉结构并绘制那里的电活动图。此类结构目前无法使用标准导管访问。
结论:这是第一项证明新型微导管结合NIOBE II技术成功用于脑血管内干预的研究。

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