The human superior parietal cortex (SPC; Brodmann areas [BA] 5 and 7) comprises the superior parietal lobule and medial wall of the intraparietal sulcus (mIPS) laterally and the posterior paracentral lobule and precuneus medially. Receptor autoradiographic and functional studies indicate more complex segregations in the SPC than suggested by Brodmann (1909). Differences to other historical maps may be due to anatomical variability between brains and different definition criteria for areas. To provide a reliable anatomical reference of the SPC, we performed an observer-independent cytoarchitectonic mapping of this region in 10 human postmortem brains. Cytoarchitecture was analyzed in cell-body-stained brain sections using gray-level index profiles. Multivariate statistical analysis of profile shape allowed the exact localization of cytoarchitectonic borders and quantification of interareal differences. We identified 3 areas in BA 5 (5L, 5M, and 5Ci), 4 in BA 7 (7PC, 7A, 7P, and 7M), and 1 in the anterior mIPS (hIP3). Locations of their borders relative to macroanatomical landmarks varied considerably between brains and hemispheres. Cytoarchitectonic profiles of areas 5Ci and hIP3 differed most from those of the remaining areas, and differences between subareas were stronger in BA 5 than in BA 7. These areas are possible structural correlates of functional segregations within the SPC.

译文

:人上顶叶皮层(SPC; Brodmann区域[BA] 5和7)包括上顶叶小叶和顶壁沟内侧壁(mIPS),以及后顶中央小叶和前突神经。受体放射自显影和功能研究表明,SPC中的分离现象比Brodmann(1909)所建议的更为复杂。与其他历史地图的差异可能是由于大脑之间的解剖变异以及针对区域的不同定义标准所致。为了提供SPC的可靠解剖学参考,我们在10个人类死后大脑中对该区域进行了独立于观察者的细胞建筑师测绘。使用灰度索引配置文件分析了细胞体染色的脑组织中的细胞结构。轮廓形状的多变量统计分析允许细胞结构边界的精确定位和区域间差异的量化。我们在BA 5中确定了3个区域(5L,5M和5Ci),在BA 7中确定了4个区域(7PC,7A,7P和7M),在前mIPS(hIP3)中确定了1个区域。相对于宏观解剖学界标,其边界的位置在大脑和半球之间差异很大。区域5Ci和hIP3的细胞结构特征与其余区域的差异最大,BA 5中的子区域之间的差异比BA 7中的强。这些区域可能是SPC中功能隔离的结构关联。

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