INTRODUCTION:Frequent use of modern imaging methods (such as ultrasound, CT and MRI) results in high incidence of accidentally discovered adrenal mass. Adrenal incidentalomas are accidentally discovered adrenal tumors by imaging methods without any prior suspicion of adrenal disease. Some studies have shown decreased insulin sensitivity in patients with adrenal incidentaloma. OBJECTIVE:The objective of our study was to assess the insulin sensitivity in patients with adrenal incidentalom a. METHOD:A total of 22 patients with accidentally discovered adrenal mass confirmed by CT/MRI were evaluated in our study. Average age was 53.31 +/- 26.5 years and average BMI 25.84 +/- 3.65 kg/m2. Control group consisted of 33 healthy subjects. Insulin sensitivity was assessed by short ITT (insulin tolerance test). Blood samples were taken before, 3, 6, 9, 12, 15, 20 and 30 minutes after i.v. bolus of regular insulin (0.05 IU/kg BW). Glycemia was determined by glucose oxidase method. Statistical analysis was done by ANCOVA, using BMI as covariate. RESULTS:Our results showed significantly lower insulin sensitivity in patients with adrenal incidentalomas comparing to the control group (4.95 +/- 0.58 vs. 6.62 +/- 0.47, p=0.015). CONCLUSION:Our patients with adrenal incidentalomas manifested lower insulin sensitivity what suggested further follow up and assessment of insulin sensitivity during endocrine evaluation of these patients.

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简介:频繁使用现代成像方法(例如超声,CT和MRI)会导致意外发现的肾上腺肿块的发生率很高。肾上腺偶发瘤是通过影像学方法意外发现的肾上腺肿瘤,而没有任何先前怀疑的肾上腺疾病。一些研究表明,肾上腺偶发瘤患者的胰岛素敏感性降低。
目的:本研究的目的是评估肾上腺偶然性a患者的胰岛素敏感性。
方法:本研究共评估22例经CT / MRI确诊的意外发现肾上腺肿块的患者。平均年龄为53.31 /-26.5岁,平均BMI为25.84 /-3.65 kg / m2。对照组由33名健康受试者组成。胰岛素敏感性通过短期ITT(胰岛素耐受性测试)进行评估。在静脉内注射之前,3、6、9、12、15、20和30分钟之前采集血样。大剂量普通胰岛素(0.05 IU / kg体重)。血糖测定采用葡萄糖氧化酶法。由ANCOVA使用BMI作为协变量进行统计分析。
结果:我们的结果显示,与对照组相比,肾上腺偶发瘤患者的胰岛素敏感性显着降低(4.95 /-0.58 vs. 6.62 /-0.47,p = 0.015)。
结论:我们的肾上腺偶发瘤患者表现出较低的胰岛素敏感性,这提示对这些患者进行内分泌评估时需要进一步随访和评估胰岛素敏感性。

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