OBJECTIVE:To analyze the clinical and EEG findings of patients with multifocal periodic lateralized epileptiform discharges (PLEDs). METHODS:EEGs containing multifocal PLEDs (3 or more foci of PLEDs) were reviewed. Thirty-five patients (15 males and 20 females), from 2.5 months to 91 years old, met the criteria for multifocal PLEDs. RESULTS:The disease processes identified in the patients included vascular lesions in 9, central nervous system infections in 7, metabolic/toxic disorders in 6, exacerbation of a chronic seizure disorder in 6, hypoxic ischemic insults in 3, and fat embolism, paraneoplastic encephalitis, cerebral metastasis, and multiple sclerosis in one each. Twenty patients died. Detection of the spatiotemporal distribution of multifocal PLEDs was facilitated by the use of Laplacian montages. CONCLUSIONS:Multifocal PLEDs were recorded in 35 patients and were associated with processes resulting in diffuse or multifocal cerebral dysfunction. Multifocal PLEDs indicate a significant disturbance of cerebral function and are associated with a mortality rate of 57%.

译文

目的:分析多灶性周期性癫痫样放电(PLEDs)患者的临床和脑电图表现。
方法:审查了包含多焦点PLED(3个或更多PLED焦点)的EEG。 2.5个月至91岁的35例患者(男15例,女20例)符合多焦点PLED的标准。
结果:在患者中确定的疾病过程包括血管病变9例,中枢神经系统感染7例,代谢/毒性障碍6例,慢性癫痫发作的加剧6例缺氧缺血性损伤3例,脂肪栓塞,副肿瘤性脑炎,脑转移和多发性硬化症各一项。 20例患者死亡。拉普拉斯蒙太奇的使用有助于检测多焦点PLED的时空分布。
结论:35例患者记录了多灶性PLED,与导致弥漫性或多灶性脑功能障碍的过程有关。多焦点PLED提示脑功能严重紊乱,死亡率为57%。

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