The effect of body mass index (BMI) and obesity on apolipoprotein (apo) A-I levels and kinetics was examined by gender. Apo A-I kinetics were determined with a primed, constant infusion of deuterated leucine in the fed state in 19 men and 13 postmenopausal women. Compared with nonobese men, nonobese women had a higher level of high-density lipoprotein cholesterol (HDL-C) and apo A-I due to a 48% higher apo A-I production rate (PR) (P = .05). Obesity had no significant effects on apo A-I kinetics in women. In contrast, compared with nonobese men, obese men had a 9% lower apo A-I level due to a 64% higher fractional catabolic rate (FCR) partially offset by a 47% higher PR. Obese women had a 52% higher HDL-C than obese men (50 vs 33 mg/dL, respectively; P = .012), a finding related to the faster apo A-I FCR in obese men. BMI was directly correlated with apo A-I FCR (r = 0.84, P < .001) and PR (r = 0.79, P < .001) in men but not in women. Sixty-two percent of the variability in PR and 71% of the variability in FCR were due to BMI in men and only 3% and 23%, respectively, in women. In conclusion, BMI has a significant effect on apo A-I PR and FCR in men but not in women.

译文

:通过性别检查了体重指数(BMI)和肥胖对载脂蛋白(apo)A-I水平和动力学的影响。在19名男性和13名绝经后女性中,在喂食状态下,经初次,恒定输注氘代亮氨酸测定了Apo A-I动力学。与非肥胖男性相比,非肥胖女性具有较高水平的高密度脂蛋白胆固醇(HDL-C)和载脂蛋白A-I,这是由于载脂蛋白A-I的产生率(PR)升高了48%(P = 0.05)。肥胖对女性的载脂蛋白A-I动力学没有显着影响。相比之下,与非肥胖男性相比,肥胖男性的分解代谢率(FCR)升高了64%,而部分PR被47%的升高所抵消,因此其apo A-I水平降低了9%。肥胖女性的HDL-C比肥胖男性高52%(分别为50和33 mg / dL; P = 0.012),这一发现与肥胖男性的apo A-I FCR更快有关。男性的BMI与apo A-I FCR(r = 0.84,P <.001)和PR(r = 0.79,P <.001)直接相关,而与女性无关。 PR变异性的62%和FCR变异性的71%是由于男性的BMI而引起的,而女性分别仅为3%和23%。总之,BMI对男性的apo A-I PR和FCR有明显影响,而对女性则没有。

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