The vitamin B12 status of 20 subjects who were on home parenteral nutrition after surgical or functional small bowel resection and were given 1000 micrograms cyanocobalamin every 3 mo was studied by comparing their plasma vitamin B12, homocysteine (HS), and methylmalonic acid (MMA) concentrations. The plasma vitamin B12 concentration (median 145 pmol/L, 95% confidence interval: 123-217) was subnormal in four cases and borderline in four others. In the "4low B12" group, the concentrations of the markers of vitamin B12 deficiency were in the normal range; HS 10.7 mumol/L (8.0-12.3); and MMA, 0.15 mumol/L (0.09-0.19). References values were HS, 10.0 mumol/L (9.4-12.6); and MMA, 0.16 mumol/L (0.10-0.19). Thus, there were no metabolic signs of vitamin B12 deficiency in these subjects on parenteral nutrition, despite the fact that their plasma vitamin B12 levels were low. Analysis of individual data showed that the four patients with low circulating B12 had markers of intracellular vitamin B12 deficiency in the normal range.

译文

:通过比较血浆中维生素B12,高半胱氨酸(HS)和甲基丙二酸(MMA)的研究,研究了20名接受手术或功能性小肠切除术后家庭肠胃外营养并每3个月接受1000微克氰钴胺素治疗的受试者的维生素B12状况浓度。血浆维生素B12浓度(中位数145 pmol / L,95%置信区间:123-217)在4例中低于正常,在其他4例中处于临界水平。在“ 4low B12”组中,维生素B12缺乏症标志物的浓度在正常范围内。 HS 10.7摩尔/升(8.0-12.3);和MMA,0.15摩尔/升(0.09-0.19)。参考值为HS,10.0 mumol / L(9.4-12.6);和MMA,0.16摩尔/升(0.10-0.19)。因此,尽管血浆维生素B12水平较低,但这些受试者在肠外营养方面没有维生素B12缺乏症的代谢迹象。对个人数据的分析显示,四名循环血B12低的患者在正常范围内具有细胞内维生素B12缺乏症的标志。

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