The nonsteroidal ecdysone mimic 1,2-dibenzoyl-1-tert-butylhydrazine (RH-5849), a novel insect growth regulator, is mainly registered for use in rice fields. So far, its toxicity and ecological risks towards aquatic cladoceran invertebrates remain unclear. In this study, RH-5849 was evaluated for its acute and 21-day chronic toxicity towards Daphnia magna. The viability, morphology, growth, and reproduction of D. magna were observed to establish a concentration-toxicity relationship associated with the RH-5849 exposure. In addition, the relationship between the changes of physiological and biochemical indices and the chronic indices was analyzed in order to find potential early warning indicators in D. magna to the chronic risk of RH-5849 exposure. The results showed that the 48-h EC50 of acute immobilization and EC50 of 21-day survival of RH-5849 on D. magna were 45.3 and 1.34 mg/L, respectively. Chronic exposure to RH-5849 mainly affected the reproductive parameters of D. magna and the no observed effect concentration (NOEC) and the EC50 were 0.050 and 0.5423 mg/L, respectively. The number of offspring per female reduced significantly after 21-day exposure to 0.10 mg/L of RH-5849. The morphological changes, manifested in head width and body length, the length of the helmet or apical spine, and the curvature and transparency of the body, were observed in RH-5849-treated groups. Moreover, it was found that the alkaline phosphatase activity in D. magna after 5-7-day exposure was positively correlated with the number of offspring per female after 21 days. These results indicate the potential risk of RH-5849 towards aquatic crustaceans should be taken into consideration when applied to rice fields.

译文

:非甾体蜕皮激素模拟1,2-二苯甲酰基-1-叔丁基肼(RH-5849)是一种新型昆虫生长调节剂,主要注册用于稻田。到目前为止,尚不清楚其对水生无脊椎无脊椎动物的毒性和生态风险。在这项研究中,对RH-5849对大型蚤(Daphnia magna)的急性和21天慢性毒性进行了评估。观察到D. magna的生存力,形态,生长和繁殖,建立了与RH-5849暴露相关的浓度-毒性关系。此外,分析了生理和生化指标的变化与慢性指标之间的关系,以发现D. magna对RH-5849暴露的慢性风险的潜在预警指标。结果显示RH-5849在大果念珠菌上的48h急性固定EC50和21天存活率EC50分别为45.3和1.34 mg / L。长期暴露于RH-5849中主要影响大果蝇的生殖参数,未观察到的有效浓度(NOEC)和EC50分别为0.050和0.5423 mg / L。暴露于0.10 mg / L RH-5849后21天,每只雌性的后代数量显着减少。在RH-5849处理组中观察到形态变化,表现为头部宽度和体长,头盔或根尖脊的长度以及身体的曲率和透明度。此外,还发现暴露5-7天后,D。magna中的碱性磷酸酶活性与21天后每只雌性的后代数量呈正相关。这些结果表明,将RH-5849应用于水生甲壳类动物的潜在风险应考虑在稻田中使用。

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